In search of partners: linking extracellular proteases to substrates (Q36735417)

16 August 2017

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title

In search of partners: linking extracellular proteases to substrates (English)

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16 August 2017

1

Christopher M Overall

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16 August 2017

Carl P Blobel

2

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16 August 2017

14 February 2007

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Nature Reviews Molecular Cell Biology

16 August 2017

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16 August 2017

8

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16 August 2017

3

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16 August 2017

245-257

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https://scigraph.springernature.com/pub.10.1038/nrm2120

16 August 2017

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cites work

AN ENZYME CASCADE IN THE BLOOD CLOTTING MECHANISM, AND ITS FUNCTION AS A BIOCHEMICAL AMPLIFIER.

1 reference

WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING.

31 March 2020

1 reference

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

31 March 2020

1 reference

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

31 March 2020

1 reference

An essential role for ectodomain shedding in mammalian development

31 March 2020

1 reference

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3

31 March 2020

1 reference

Matrix metalloproteinases as modulators of inflammation and innate immunity

31 March 2020

1 reference

Epithelial cell motility on laminin-5: regulation by matrix assembly, proteolysis, integrins and erbB receptors

31 March 2020

1 reference

Angiostatin induces and sustains dormancy of human primary tumors in mice

31 March 2020

1 reference

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice

31 March 2020

1 reference

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

31 March 2020

1 reference

Targeting proteases: successes, failures and future prospects

31 March 2020

1 reference

Protease degradomics: a new challenge for proteomics

31 March 2020

1 reference

Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases

31 March 2020

1 reference

Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17).

31 March 2020

1 reference

Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorption

31 March 2020

1 reference

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates

31 March 2020

1 reference

HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration

31 March 2020

1 reference

31 March 2020

Genomics and proteomics

1 reference

Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity

31 March 2020

1 reference

Human ADAM 12 (meltrin alpha) is an active metalloprotease.

31 March 2020

1 reference

Catalytic activity of human ADAM33

31 March 2020

1 reference

Rapid identification of highly active and selective substrates for stromelysin and matrilysin using bacteriophage peptide display libraries

31 March 2020

1 reference

Substrate phage: selection of protease substrates by monovalent phage display

31 March 2020

1 reference

Rapid identification of substrates for novel proteases using a combinatorial peptide library

31 March 2020

1 reference

Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes

31 March 2020

1 reference

Engineering human prolactin to bind to the human growth hormone receptor

31 March 2020

1 reference

The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38).

31 March 2020

1 reference

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

31 March 2020

1 reference

Peptide microarrays for the determination of protease substrate specificity

31 March 2020

1 reference

High density peptide microarrays. In situ synthesis and applications

31 March 2020

1 reference

Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor

31 March 2020

1 reference

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design

31 March 2020

1 reference

Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence

31 March 2020

1 reference

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

31 March 2020

1 reference

Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs)

31 March 2020

1 reference

Structural aspects of the metzincin clan of metalloendopeptidases.

31 March 2020

1 reference

Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites

31 March 2020

1 reference

The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage

31 March 2020

1 reference

A model for interstitial collagen catabolism by mammalian collagenases

31 March 2020

1 reference

PoPS: a computational tool for modeling and predicting protease specificity.

31 March 2020

1 reference

Discovery of chemokine substrates for matrix metalloproteinases by exosite scanning: a new tool for degradomics

31 March 2020

1 reference

The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity

31 March 2020

1 reference

ADAMTS1 interacts with, cleaves, and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2.

31 March 2020

1 reference

Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors

31 March 2020

1 reference

A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration

31 March 2020

1 reference

Regulation of Human ADAM 12 Protease by the Prodomain

31 March 2020

1 reference

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

31 March 2020

1 reference

A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2.

31 March 2020

1 reference

Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II

31 March 2020

1 reference

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

31 March 2020

1 reference

Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx

31 March 2020

1 reference

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

31 March 2020

1 reference

Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency

31 March 2020

1 reference

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

31 March 2020

1 reference

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

31 March 2020

1 reference

Proteomic validation of protease drug targets: pharmacoproteomics of matrix metalloproteinase inhibitor drugs using isotope-coded affinity tag labelling and tandem mass spectrometry

31 March 2020

1 reference

Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation

31 March 2020

1 reference

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

31 March 2020

1 reference

Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

31 March 2020

1 reference

A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma.

31 March 2020

1 reference

Identification of caspase-3 degradome by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight analysis

31 March 2020

1 reference

Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex

31 March 2020

1 reference

A proteomic approach for the discovery of protease substrates

31 March 2020

1 reference

Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis

31 March 2020

1 reference

Large-scale analysis of the yeast proteome by multidimensional protein identification technology

31 March 2020

1 reference

A proteomic approach to characterize protein shedding

31 March 2020

1 reference

A proteomic approach for the identification of cell-surface proteins shed by metalloproteases

31 March 2020

1 reference

Intramembrane proteolysis by presenilin and presenilin-like proteases

31 March 2020

1 reference

Differential dimethyl labeling of N-termini of peptides after guanidination for proteome analysis

31 March 2020

1 reference

Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis.

31 March 2020

1 reference

Positional proteomics: selective recovery and analysis of N-terminal proteolytic peptides

31 March 2020

1 reference

Peptidomics: the comprehensive analysis of peptides in complex biological mixtures

31 March 2020

1 reference

Exploiting natural peptide diversity: novel research tools and drug leads

31 March 2020

1 reference

Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry

31 March 2020

1 reference

The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study.

31 March 2020

1 reference

New functions for the matrix metalloproteinases in cancer progression

31 March 2020

1 reference

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

31 March 2020

1 reference

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

31 March 2020

1 reference

MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.

31 March 2020

1 reference

Control of peripheral nerve myelination by the beta-secretase BACE1

31 March 2020

1 reference

Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer

31 March 2020

1 reference

ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.

31 March 2020

1 reference

Potential role for ADAM15 in pathological neovascularization in mice

31 March 2020

1 reference

Activity-based probes for the proteomic profiling of metalloproteases

31 March 2020

1 reference

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

31 March 2020

1 reference

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

31 March 2020

1 reference

Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.

31 March 2020

1 reference

Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

31 March 2020

1 reference

BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein

31 March 2020

1 reference

A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase

31 March 2020

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Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

31 March 2020

1 reference

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

31 March 2020

1 reference

De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent

31 March 2020

1 reference

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

31 March 2020

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Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase

31 March 2020

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Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand

31 March 2020

1 reference

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

31 March 2020

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Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

31 March 2020

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Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury.

31 March 2020

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

31 March 2020

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

31 March 2020

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

31 March 2020

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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

31 March 2020

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Human and mouse proteases: a comparative genomic approach

31 March 2020

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Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

31 March 2020

1 reference

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

31 March 2020

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Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE).

31 March 2020

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X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design

31 March 2020

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Inhibitory antibodies against endopeptidase activity of human adamalysin 19

31 March 2020

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Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha

31 March 2020

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Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail

31 March 2020

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Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain

31 March 2020

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Aptamers as tools for target validation

31 March 2020

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Gene discovery by ribozyme and siRNA libraries

31 March 2020

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Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter

31 March 2020

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Identifiers

DOI

10.1038/NRM2120

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16 August 2017

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PubMed ID

17299501