Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases (Q34172256)

31 July 2017

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases (English)

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31 July 2017

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Davidson HW

1

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31 July 2017

Rhodes CJ

series ordinal

2

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31 July 2017

Hutton JC

series ordinal

3

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31 July 2017

language of work or name

English

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publication date

1 May 1988

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31 July 2017

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31 July 2017

333

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93-96

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6168

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https://scigraph.springernature.com/pub.10.1038/333093a0

31 July 2017

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cites work

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The internal pH and membrane potential of the insulin-secretory granule

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Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate

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Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles

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The electron microscopic localization of cations to pancreatic islets of langerhans and their possible role in insulin secretion

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Ca-activated ATPase activity in subcellular fractions of mouse pancreatic islets

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Calcium and pancreatic β-cell function6. glucose and intracellular 45Ca distribution

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Biosynthesis of betagranin in pancreatic beta-cells. Identification of a chromogranin A-like precursor and its parallel processing with proinsulin.

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Biosynthesis of insulin secretory granule membrane proteins. Control by glucose.

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Role of zinc and calcium in the formation and storage of insulin in the pancreatic ?-cell

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Direct effects of glucose on proinsulin synthesis and processing during desensitization

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Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway

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Use of a synthetic peptide antigen to generate antisera reactive with a proteolytic processing site in native human proinsulin: demonstration of cleavage within clathrin-coated (pro)secretory vesicles

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Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

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Secretion and processing of insulin precursors in yeast

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Calcium-dependent KEX2-like protease found in hepatic secretory vesicles converts proalbumin to albumin.

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Concentration of MgATP2- and other ions in solution. Calculation of the true concentrations of species present in mixtures of associating ions

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Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

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Identifiers

DOI

10.1038/333093A0

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Dimensions Publication ID

31 July 2017

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