Blood-brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics (Q38267318)

1 September 2017

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title

Blood-brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics (English)

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1 September 2017

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Danica B Stanimirovic

1

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1 September 2017

Mahmud Bani-Yaghoub

2

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1 September 2017

Martin Perkins

3

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1 September 2017

Arsalan S Haqqani

4

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1 September 2017

language of work or name

English

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publication date

12 November 2014

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Expert Opinion on Drug Discovery

1 September 2017

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1 September 2017

10

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1 September 2017

2

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1 September 2017

141-155

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Trial watch: phase II and phase III attrition rates 2011-2012.

1 September 2017

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Structure and function of the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

CNS drug development - lost in translation?

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Engaging neuroscience to advance translational research in brain barrier biology.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Development, maintenance and disruption of the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Astrocyte-endothelial interactions at the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

In vitro modeling of the blood-brain barrier: simplicity versus complexity

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

In vitro model for evaluating drug transport across the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Patented in vitro blood-brain barrier models in CNS drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB).

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

In vitro models for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

The hCMEC/D3 cell line as a model of the human blood brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Laminin isoforms in endothelial and perivascular basement membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: an in vitro study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Dynamics of CNS barriers: evolution, differentiation, and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Retinoic acid induces blood-brain barrier development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Immortalization of brain capillary endothelial cells with maintenance of structural characteristics of the blood-brain barrier endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Establishment of a line of human fetal glial cells that supports JC virus multiplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Electrical resistance of brain microvascular endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Zebrafish approaches enhance the translational research tackle box.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Claudin-5a in developing zebrafish brain barriers: another brick in the wall

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Zebrafish model of the blood-brain barrier: morphological and permeability studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Zebrafish as a model to study drug transporters at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Zebrafish models for translational neuroscience research: from tank to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Involvement of P-glycoprotein in blood-brain barrier transport of pentazocine in rats using brain uptake index method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Quantitation and localization of blood-to-brain influx by magnetic resonance imaging and quantitative autoradiography in a model of transient focal ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

The use of microdialysis in CNS drug delivery studies. Pharmacokinetic perspectives and results with analgesics and antiepileptics

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2015.974545

CSF as a surrogate for assessing CNS exposure: an industrial perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Methods to assess drug permeability across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Imaging blood-brain barrier dysfunction in animal disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

On the rate and extent of drug delivery to the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Engineering and pharmacology of blood-brain barrier-permeable bispecific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Validation of in vitro cell-based human blood-brain barrier model using clinical positron emission tomography radioligands to predict in vivo human brain penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Diffusion of macromolecules in the brain: implications for drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Blood-brain barrier transport of therapeutics via receptor-mediation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Drug targeting to the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Multiplexed evaluation of serum and CSF pharmacokinetics of brain-targeting single-domain antibodies using a NanoLC-SRM-ILIS method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Drug development for CNS disorders: strategies for balancing risk and reducing attrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Pericytes from Brain Microvessels Strengthen the Barrier Integrity in Primary Cultures of Rat Brain Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.974545

Blood-brain barrier-specific properties of a human adult brain endothelial cell line

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1096/FJ.04-3458FJE

Identifiers

DOI

10.1517/17460441.2015.974545

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release_tyyxvrqxnbbkvm2bgtydekj3ae

1 September 2017

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Fatcat

https://api.fatcat.wiki/v0/release/tyyxvrqxnbbkvm2bgtydekj3ae

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference