Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain. (Q32181067)

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English	Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain.	scientific article

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11 November 2019

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Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain (English)

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11 November 2019

cerebrospinal fluid

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pharmacokinetics

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based on heuristic

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Elizabeth C de Lange

1

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11 November 2019

Meindert Danhof

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Meindert Danhof

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1 January 2002

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Clinical Pharmacokinetics

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https://scigraph.springernature.com/pub.10.2165/00003088-200241100-00001

0 references

Ultrastructural characteristics of the brain and blood-brain barrier in experimental seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of brain delivery of ofloxacin, a new quinolone, in the human from animal data

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxepin and its metabolites in plasma and cerebrospinal fluid in depressed patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain and CSF entry of the novel non-nucleoside reverse transcriptase inhibitor, GW420867X.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceftriaxone pharmacokinetics in the central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic evidence for active efflux transport across the blood-brain barrier of quinolone antibiotics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Measurement of CSF flow in the spinal canal using MRI with an optimized MRI protocol: experimental and clinical studies]

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of propranolol and lidocaine through the rat blood-brain barrier. Primary role of globulin-bound drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The simultaneous estimation of the influx and efflux blood-brain barrier permeabilities of gabapentin using a microdialysis-pharmacokinetic approach.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of protein binding determine rates of uptake of drugs by brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative structure-activity relationship of multidrug resistance reversal agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Principles of brain tumor chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular phosphorylation of zidovudine (ZDV) and other nucleoside reverse transcriptase inhibitors (RTI) used for human immunodeficiency virus (HIV) infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The spinal loop dialysis catheter: characterization of use in the unanesthetized rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between macrophages and brain microvascular endothelial cells: role in pathogenesis of HIV-1 infection and blood - brain barrier function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid solubility and drug penetration of the blood brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The permeability of the blood-brain barrier during electrically induced seizures in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant enzymes and related trace elements in aging brain capillaries and choroid plexus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and Function of the Choroid Plexus and Other Sites of Cerebrospinal Fluid Formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

19F nuclear magnetic resonance spectroscopy of neuroleptics: the first in vivo pharmacokinetics of trifluoperazine in the rat brain and the first in vivo spectrum of fluphenazine in the human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pathophysiology of pneumococcal meningitis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The blood-brain barrier in neuroinflammatory diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of drug-metabolizing enzyme activities to blood-brain interfaces and circumventricular organs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell biology of the blood-brain barrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of microdialysis in CNS drug delivery studies. Pharmacokinetic perspectives and results with analgesics and antiepileptics

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructural cytochemistry of blood-brain barrier endothelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of carbon-11 labeled iodinated cocaine derivatives and their distribution in baboon brain measured using positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-to-brain transfer of various oxicams: effects of plasma binding on their brain delivery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mammalian choroid plexus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular microenvironment in gliomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-brain barrier penetration of felbamate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Report of a meeting: molecular basis of cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The entry of antiviral and antiretroviral drugs into the central nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ependymal development, proliferation, and functions: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microdialysis in the study of drug transporters in the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Magnetisation transfer imaging in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of intravenous dose and schedule on cerebrospinal fluid pharmacokinetics of 5-fluorouracil in the monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ependyma: a protective barrier between brain and cerebrospinal fluid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central nervous side effects after lumbar puncture. A review of the possible pathogenesis of the syndrome of postdural puncture headache and associated symptoms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distributed model for drug delivery to CSF and brain tissue.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of albumin and alpha 1-acid glycoprotein on the transport of imipramine and desipramine through the blood-brain barrier in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-brain barrier permeability during the development of experimental bacterial meningitis in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by various convulsive agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of probenecid on brain-cerebrospinal fluid-blood distribution kinetics of E-Delta 2-valproic acid in rabbits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology and pathology of the blood-brain barrier: implications for microbial pathogenesis, drug delivery and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of distribution, transport and uptake of anti-HIV drugs to the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitated transport of melphalan at the rat blood-brain barrier by the large neutral amino acid carrier system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of material between brain extracellular fluid, brain cells and blood.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of serum, cerebrospinal fluid and brain extracellular fluid pharmacokinetics of lamotrigine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of lamivudine and BCH-189 in plasma and cerebrospinal fluid of nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroblastoma metastatic to the central nervous system. The Memorial Sloan-kettering Cancer Center Experience and A Literature Review

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Problems of delivery of drugs to the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-protein binding and blood-brain barrier permeability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A general pattern for substrate recognition by P-glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The choroid plexus epithelium is the site of the organic anion transport protein in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid production is normal in Down syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione S-transferase isoenzymes in rat brain neurons and glia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple actions of steroid hormones--a focus on rapid, nongenomic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of anticancer drugs in cerebrospinal fluid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusion of 3-quaternary ammonium cephem antibiotics into cerebrospinal fluid of patients with bacterial meningitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of phenytoin-inducible cytochrome P450 immunoreactivity in the mouse central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in understanding the pharmacology of agents used to treat bacterial meningitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the binding of isradipine and darodipine to different plasma proteins on their transfer through the rat blood-brain barrier. Drug binding to lipoproteins does not limit the transfer of drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo evidence for carrier-mediated efflux transport of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine(B)-site: microdialysis and maximum electroshock seizures studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new aspect of the protective functions of the blood-brain barrier: activities of four drug-metabolizing enzymes in isolated rat brain microvessels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability of the blood-brain barrier for atenolol studied by positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent advances in blood-brain barrier transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in function and structure of the capillary endothelium in gray matter, white matter and a circumventricular organ of rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A study of intrathecal, cerebrospinal fluid-to-brain exchange.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the Mdr1a P-glycoprotein gene disruption on the tissue distribution of SDZ PSC 833, a multidrug resistance-reversing agent, in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic study of trimethadione and its metabolite in blood, liver and brain by microdialysis in conscious, unrestrained rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microdialysis in clinical drug delivery studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiepileptic drug pharmacokinetics and neuropharmacokinetics in individual rats by repetitive withdrawal of blood and cerebrospinal fluid: phenytoin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organic anion transport across the choroid plexus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologic considerations for therapeutic success with antiretroviral agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology of the choroid plexus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carrier-mediated or specialized transport of drugs across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homeostatic role of the active transport in elimination of [3H]benzylpenicillin out of the cerebrospinal fluid system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of the distribution of EAB 515 to cortical ECF and CSF in freely moving rats utilizing microdialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced expression by the brain matrix of P-glycoprotein in brain capillary endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of brain endothelial permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of blood-brain barrier permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/12162757

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003088-200241100-00001

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12162757%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Dimensions Publication ID

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12162757%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

ResearchGate publication ID

0 references

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