Combating neurodegenerative disease with chemical probes and model systems (Q38261089)

1 September 2017

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title

Combating neurodegenerative disease with chemical probes and model systems (English)

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1 September 2017

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3

Susan Lindquist

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1 September 2017

2

Sepehr Ehsani

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1 September 2017

Priyanka Narayan

1

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1 September 2017

17 October 2014

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1 September 2017

Nature Chemical Biology

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1 September 2017

10

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1 September 2017

11

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1 September 2017

911-920

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https://scigraph.springernature.com/pub.10.1038/nchembio.1663

1 September 2017

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cites work

Genetics. Human genetic variation, shared and private

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

The therapeutics of Alzheimer's disease: where we stand and where we are heading

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Adapting proteostasis for disease intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Mechanisms of protein-folding diseases at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

HSP90 and the chaperoning of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

The cell-non-autonomous nature of electron transport chain-mediated longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Autophagy fights disease through cellular self-digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Aging as an event of proteostasis collapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Sorting out the trash: the spatial nature of eukaryotic protein quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

The role of the unfolded protein response in tumour development: friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Unfolding the role of protein misfolding in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Proteome half-life dynamics in living human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

DNA damage and its links to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Constitutional aneuploidy in the normal human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Aneuploidy: implications for protein homeostasis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Neuropathologic changes of multiple system atrophy and diffuse Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

The secretases: enzymes with therapeutic potential in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Protein localization in disease and therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Small-molecule proteostasis regulators for protein conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Molecular genetics of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Pharmacological chaperones stabilize retromer to limit APP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Drosophila as a model for human neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

SMN is required for sensory-motor circuit function in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

A Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Genetic and chemical modifiers of a CUG toxicity model in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

A functional variomics tool for discovering drug-resistance genes and drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

How were new medicines discovered?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

iPS cells: a game changer for future medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Enhanced aggregation of androgen receptor in induced pluripotent stem cell-derived neurons from spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

A TALEN genome-editing system for generating human stem cell-based disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Genetic screens in human cells using the CRISPR-Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Human iPSC-based modeling of late-onset disease via progerin-induced aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

FoldEco: a model for proteostasis in E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Metabolite-initiated protein misfolding may trigger Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Deregulation of sphingolipid metabolism in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

RNA-mediated toxicity in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Circadian clocks and neurodegenerative diseases: time to aggregate?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Regulation of organismal proteostasis by transcellular chaperone signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Prion-like transmission of protein aggregates in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Innate immune activation in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

Drug discovery in dementia: the role of rodent models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1663

From yeast to patient neurons and back again: powerful new discovery platform

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25325702

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25325702

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25325702

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1663

1 reference

1 September 2017

1 reference

PubMed ID

25325702