Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures (Q38240696)

31 August 2017

Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures (English)

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31 August 2017

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3

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31 August 2017

Philipp Trepte

1

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Nadine Strempel

series ordinal

2

object named as

Nadine Strempel

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31 August 2017

1 January 2014

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31 August 2017

Essays in Biochemistry

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31 August 2017

56

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31 August 2017

167-180

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Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks.

31 August 2017

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https://api.crossref.org/works/10.1042%2FBSE0560167

Polyglutamine tracts as modulators of transcriptional activation from yeast to mammals.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Functional conservation of the glutamine-rich domains of yeast Gal11 and human SRC-1 in the transactivation of glucocorticoid receptor Tau 1 in Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Polyglutamine gene function and dysfunction in the ageing brain

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

HEAT repeats in the Huntington's disease protein

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Huntingtin interacts with a family of WW domain proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Normal huntingtin function: an alternative approach to Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin protein

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Cellular inclusion bodies of mutant huntingtin exon 1 obscure small fibrillar aggregate species

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

The hunt for huntingtin function: interaction partners tell many different stories

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Protein aggregation and neurodegenerative disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Misfolded proteins partition between two distinct quality control compartments

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Identification of a candidate therapeutic autophagy-inducing peptide

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Acetylation targets mutant huntingtin to autophagosomes for degradation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Small-molecule proteostasis regulators for protein conformational diseases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560167

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

Drosophila as a model for human neurodegenerative disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBSE0560167

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSE0560167

21 January 2018

Identifiers

DOI

10.1042/BSE0560167

1 reference

31 August 2017

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PubMed ID

25131594