Discovery and preclinical development of vismodegib (Q38214255)

31 August 2017

Discovery and preclinical development of vismodegib (English)

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31 August 2017

1

Stephen E Gould

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31 August 2017

5

Lee L Rubin

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31 August 2017

Jennifer A Low

2

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31 August 2017

James C Marsters

3

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31 August 2017

Kirk Robarge

4

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31 August 2017

Frederic J de Sauvage

6

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31 August 2017

Daniel P Sutherlin

7

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31 August 2017

Harvey Wong

8

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31 August 2017

Robert L Yauch

9

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31 August 2017

language of work or name

English

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publication date

23 May 2014

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Expert Opinion on Drug Discovery

31 August 2017

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31 August 2017

9

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31 August 2017

8

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31 August 2017

969-984

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Mutations affecting segment number and polarity in Drosophila

31 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog signaling in animal development: paradigms and principles

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Shifting paradigms in Hedgehog signaling

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Shh and Ptc are associated with taste bud maintenance in the adult mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Sertoli cell signaling by Desert hedgehog regulates the male germline

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

The controversial role of the Hedgehog pathway in normal and malignant hematopoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog: functions and mechanisms

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Orchestrating ontogenesis: variations on a theme by sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Patched acts catalytically to suppress the activity of Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

The Niemann-Pick C lesion and its relationship to the intracellular distribution and utilization of LDL cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

The Hedgehog signal transduction network

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Catching a Gli-mpse of Hedgehog

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Gli and hedgehog in cancer: tumours, embryos and stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Allelic loss at Drosophila patched gene is highly prevalent in Basal and squamous cell carcinomas of the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Basal cell carcinoma development is associated with induction of the expression of the transcription factor Gli-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Nevoid basal cell carcinoma (Gorlin) syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

A mouse model for medulloblastoma and basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Medulloblastomics: the end of the beginning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

The hedgehog pathway and neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Potent inhibitors of the hedgehog signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Small molecule modulation of Smoothened activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

GDC-0449-a potent inhibitor of the hedgehog pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Efficacy and safety of vismodegib in advanced basal-cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

A phase II, randomized, placebo-controlled study of vismodegib as maintenance therapy in patients with ovarian cancer in second or third complete remission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

Hedgehog pathway inhibitors: a patent review (2009--present).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.920816

10.1517/17460441.2014.920816

21 January 2018

Identifiers

DOI

1 reference

31 August 2017

1 reference