Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling (Q42143326)

17 October 2017

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling (English)

1 reference

17 October 2017

20α-hydroxycholesterol

1 reference

ChEBI release 2020-05-28

Daniel Nedelcu

1

1 reference

17 October 2017

Jing Liu

2

1 reference

17 October 2017

Yangqing Xu

3

1 reference

17 October 2017

Cindy Jao

4

1 reference

17 October 2017

Adrian Salic

5

1 reference

17 October 2017

7 July 2013

1 reference

17 October 2017

Nature Chemical Biology

1 reference

17 October 2017

9

1 reference

17 October 2017

9

1 reference

17 October 2017

557-564

1 reference

https://scigraph.springernature.com/pub.10.1038/nchembio.1290

17 October 2017

0 references

cites work

A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Structural basis of Wnt recognition by Frizzled

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Oxysterols are allosteric activators of the oncoprotein Smoothened

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

GDC-0449-a potent inhibitor of the hedgehog pathway

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Patched1 regulates hedgehog signaling at the primary cilium

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

20(S)-hydroxycholesterol inhibits PPARgamma expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Vertebrate Smoothened functions at the primary cilium

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

The Hedgehog response network: sensors, switches, and routers

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Small molecule modulation of Smoothened activity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Patched acts catalytically to suppress the activity of Smoothened

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Hedgehog signaling in animal development: paradigms and principles

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Structural ties between cholesterol transport and morphogen signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749252

Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23831757

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1290

1 reference

17 October 2017

1 reference

17 October 2017

1 reference