Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. (Q37593483)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300762%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300762%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

main subject

phase I clinical trial

0 references

0 references

2

1 reference

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21 January 2020

Josina C. Reddy

3

1 reference

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21 January 2020

author name string

Patricia M LoRusso

1

1 reference

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21 January 2020

Raoul Tibes

4

1 reference

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21 January 2020

Glen J Weiss

5

1 reference

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21 January 2020

Mitesh J Borad

6

1 reference

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21 January 2020

Christine L Hann

7

1 reference

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21 January 2020

Julie R Brahmer

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300762%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Ilsung Chang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300762%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Walter C Darbonne

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300762%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Richard A Graham

11

1 reference

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21 January 2020

Kenn L Zerivitz

12

1 reference

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21 January 2020

Jennifer A Low

13

1 reference

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21 January 2020

Daniel D Von Hoff

14

1 reference

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21 January 2020

language of work or name

English

0 references

publication date

7 February 2011

1 reference

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21 January 2020

published in

Clinical Cancer Research

1 reference

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21 January 2020

volume

17

1 reference

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21 January 2020

page(s)

2502-2511

1 reference

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21 January 2020

issue

8

1 reference

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Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein binding

21 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Basal cell carcinomas: attack of the hedgehog

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Essential role of stromally induced hedgehog signaling in B-cell malignancies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Hedgehog signaling in animal development: paradigms and principles

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Activating Smoothened mutations in sporadic basal-cell carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

The gene for the naevoid basal cell carcinoma syndrome acts as a tumour-suppressor gene in medulloblastoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

GDC-0449-a potent inhibitor of the hedgehog pathway

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

A paracrine requirement for hedgehog signalling in cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Hedgehog signaling promotes prostate xenograft tumor growth

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Sporadic medulloblastomas contain PTCH mutations.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5244484

Targeting the Hedgehog pathway in cancer

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21300762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A CONGENITAL CYCLOPIAN-TYPE MALFORMATION IN LAMBS INDUCED BY MATERNAL INGESTION OF A RANGE PLANT, VERATRUM CALIFORNICUM

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21300762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21300762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1078-0432.CCR-10-2745

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300762%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21300762%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference