Antiviral strategies against influenza virus: towards new therapeutic approaches (Q38202012)

30 August 2017

Antiviral strategies against influenza virus: towards new therapeutic approaches (English)

1 reference

30 August 2017

1

Arianna Loregian

1 reference

30 August 2017

5

Giorgio Palù

1 reference

30 August 2017

Beatrice Mercorelli

2

1 reference

PubMed ID

24699705

30 August 2017

Giulio Nannetti

series ordinal

3

1 reference

PubMed ID

24699705

30 August 2017

Chiara Compagnin

series ordinal

4

1 reference

30 August 2017

4 April 2014

1 reference

Cellular and Molecular Life Sciences

30 August 2017

1 reference

30 August 2017

71

1 reference

30 August 2017

3659-3683

1 reference

30 August 2017

19

1 reference

https://scigraph.springernature.com/pub.10.1007/s00018-014-1615-2

30 August 2017

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21 January 2018

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Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

21 January 2018

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Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

21 January 2018

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Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

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Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication

21 January 2018

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21 January 2018

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The structural basis for an essential subunit interaction in influenza virus RNA polymerase

21 January 2018

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Identification of influenza virus inhibitors which disrupt of viral polymerase protein-protein interactions

21 January 2018

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A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly

21 January 2018

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The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.

21 January 2018

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Nuclear export of influenza A virus mRNAs requires ongoing RNA polymerase II activity

21 January 2018

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The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA

21 January 2018

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Organization of the influenza virus replication machinery

21 January 2018

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Structure and assembly of the influenza A virus ribonucleoprotein complex

21 January 2018

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Design, synthesis, and in vitro biological evaluation of 1H-1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein

21 January 2018

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Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching

21 January 2018

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Identification of influenza A nucleoprotein as an antiviral target

21 January 2018

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E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors

21 January 2018

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High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity

21 January 2018

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Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus

21 January 2018

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5'-Triphosphate-short interfering RNA: potent inhibition of influenza A virus infection by gene silencing and RIG-I activation.

21 January 2018

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Protection against lethal influenza virus challenge by RNA interference in vivo.

21 January 2018

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Monomeric Nucleoprotein of Influenza A Virus

21 January 2018

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Structure of influenza virus ribonucleoprotein particles. II. Purified RNA-free influenza virus ribonucleoprotein forms structures that are indistinguishable from the intact influenza virus ribonucleoprotein particles

21 January 2018

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Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection

21 January 2018

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The multifunctional NS1 protein of influenza A viruses

21 January 2018

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Strain-specific contribution of NS1-activated phosphoinositide 3-kinase signaling to influenza A virus replication and virulence

21 January 2018

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The RNA-binding domain of influenzavirus non-structural protein-1 cooperatively binds to virus-specific RNA sequences in a structure-dependent manner

21 January 2018

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Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.

21 January 2018

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The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway

21 January 2018

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Contribution of double-stranded RNA and CPSF30 binding domains of influenza virus NS1 to the inhibition of type I interferon production and activation of human dendritic cells

21 January 2018

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RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids

21 January 2018

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Development of an HTS assay for the search of anti-influenza agents targeting the interaction of viral RNA with the NS1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Identification of influenza virus inhibitors targeting NS1A utilizing fluorescence polarization-based high-throughput assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Human host factors required for influenza virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Emerging cellular targets for influenza antiviral agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Drosophila RNAi screen identifies host genes important for influenza virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

The host interactome of influenza virus presents new potential targets for antiviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Analysis of the interaction of influenza virus polymerase complex with human cell factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Cleavage of influenza a virus hemagglutinin in human respiratory epithelium is cell associated and sensitive to exogenous antiproteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Suppression of Influenza Virus Replication in Infected Mice by Protease Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Aprotinin, a protease inhibitor, suppresses proteolytic activation of pandemic H1N1v influenza virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

The use of sialidase therapy for respiratory viral infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Phenotypic and genotypic characterization of influenza virus mutants selected with the sialidase fusion protein DAS181.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

A phase II study of DAS181, a novel host directed antiviral for the treatment of influenza infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Lipid raft disruption by cholesterol depletion enhances influenza A virus budding from MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Host factors for replication and transcription of the influenza virus genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Hsp90 inhibitors reduce influenza virus replication in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Bcl-2 expression and p38MAPK activity in cells infected with influenza A virus: impact on virally induced apoptosis and viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

MEK inhibition impairs influenza B virus propagation without emergence of resistant variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Inhibition of influenza infection by glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Redox regulation of the influenza hemagglutinin maturation process: a new cell-mediated strategy for anti-influenza therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Effects of polyphenol compounds on influenza A virus replication and definition of their mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Combination of MEK inhibitors and oseltamivir leads to synergistic antiviral effects after influenza A virus infection in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Autophagy is involved in influenza A virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Inhibition of influenza A virus replication by antagonism of a PI3K-AKT-mTOR pathway member identified by gene-trap insertional mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Active NF-kappaB signalling is a prerequisite for influenza virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

NF-kappaB-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient influenza virus propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Effect of antioxidants on apoptosis induced by influenza virus infection: inhibition of viral gene replication and transcription with pyrrolidine dithiocarbamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Antioxidant therapy as a potential approach to severe influenza-associated complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Degradation of cellular mRNA during influenza virus infection: its possible role in protein synthesis shutoff

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

D282, a non-nucleoside inhibitor of influenza virus infection that interferes with de novo pyrimidine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Lessons from lipids in the fight against influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Induction and evasion of type I interferon responses by influenza viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Identification of small molecules with type I interferon inducing properties by high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Inhibition of influenza virus multiplication by alkyl derivatives of benzimidazole. II. Measurement of inhibitory activity by hemagglutination titrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Inhibition of nuclear export of ribonucleoprotein complexes of influenza virus by leptomycin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

A small molecule multi-kinase inhibitor reduces influenza A virus replication by restricting viral RNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Comment on: concerns of using sialidase fusion protein as an experimental drug to combat seasonal and pandemic influenza

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-014-1615-2

Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity

21 January 2018

1 reference

12 December 2020

Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents

1 reference

12 December 2020

Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.

1 reference

12 December 2020

PI3 kinase inhibitors in the clinic: an update

1 reference

12 December 2020

Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment.

1 reference

12 December 2020

Discovery of novel influenza inhibitors targeting the interaction of dsRNA with the NS1 protein by structure-based virtual screening

1 reference

12 December 2020

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease

1 reference

12 December 2020

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

1 reference

12 December 2020

Influenza virus and redox mediated cell signaling: a complex network of virus/host interaction.

1 reference

12 December 2020

Amantadine-oseltamivir combination therapy for H5N1 influenza virus infection in mice.

1 reference

12 December 2020

A novel antiviral agent which inhibits the endonuclease of influenza viruses

1 reference

12 December 2020

Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo.

1 reference

12 December 2020

Influenza A virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2.

1 reference

12 December 2020

Biochemical and Structural Evidence in Support of a Coherent Model for the Formation of the Double-Helical Influenza A Virus Ribonucleoprotein

1 reference

12 December 2020

A novel class of potent NF-kappaB signaling inhibitors

1 reference

12 December 2020

How do aminoadamantanes block the influenza M2 channel, and how does resistance develop?

1 reference

12 December 2020

Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins

1 reference

12 December 2020

Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza

1 reference

12 December 2020

How academic labs can approach the drug discovery process as a way to synergize with big pharma

1 reference

12 December 2020

[Protein kinase inhibitor flavopiridol inhibits the replication of influenza virus in vitro]

1 reference

12 December 2020

Clinical effectiveness of aprotinin aerosol in influenza and parainfluenza

1 reference

12 December 2020

Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus

1 reference

12 December 2020

A 48-amino-acid region of influenza A virus PB1 protein is sufficient for complex formation with PA.

1 reference

12 December 2020

A novel family of peptides with potent activity against influenza A viruses

1 reference

12 December 2020

10.1007/S00018-014-1615-2

Identifiers

DOI

1 reference

30 August 2017

1 reference

PubMed ID

24699705