Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase (Q27655568)

1

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Eiji Obayashi

2

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Atsushi Kawaguchi

3

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Yukari Suzuki

4

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Jeremy R H Tame

5

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Kyosuke Nagata

6

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Sam-Yong Park

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

7

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language of work or name

English

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publication date

17 June 2009

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published in

The EMBO Journal

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volume

28

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page(s)

1803-11

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issue

12

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cites work

1 reference

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Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site

20 March 2017

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Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

20 March 2017

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The structural basis for an essential subunit interaction in influenza virus RNA polymerase

20 March 2017

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Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus

20 March 2017

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The structural basis for cap binding by influenza virus polymerase subunit PB2

20 March 2017

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Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

20 March 2017

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Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase

20 March 2017

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Inference of macromolecular assemblies from crystalline state

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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SOLVE and RESOLVE: automated structure solution and density modification

20 March 2017

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Automated MAD and MIR structure solution

20 March 2017

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Main-chain bond lengths and bond angles in protein structures

20 March 2017

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LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

20 March 2017

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Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates

20 March 2017

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Influenza A virus RNA polymerase has the ability to stutter at the polyadenylation site of a viral RNA template during RNA replication

20 March 2017

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RNA-dependent activation of primer RNA production by influenza virus polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites

20 March 2017

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Identification of two separate domains in the influenza virus PB1 protein involved in the interaction with the PB2 and PA subunits: a model for the viral RNA polymerase structure.

20 March 2017

1 reference

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A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription

20 March 2017

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Characterization of the 1918 influenza virus polymerase genes

20 March 2017

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Differential activation of the influenza virus polymerase via template RNA binding

20 March 2017

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Generation of influenza A viruses entirely from cloned cDNAs

20 March 2017

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Host factors for replication and transcription of the influenza virus genome.

7 April 2017

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Evidence that the C-terminal PB2-binding region of the influenza A virus PB1 protein is a discrete alpha-helical domain

29 September 2017

1 reference

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Avian influenza virus (H5N1): a threat to human health.

29 September 2017

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A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2699363

Fine mapping of the subunit binding sites of influenza virus RNA polymerase

29 September 2017

1 reference

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The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication.

29 September 2017

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Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template

29 September 2017

1 reference

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Molecular assembly of the influenza virus RNA polymerase: determination of the subunit-subunit contact sites

29 September 2017

1 reference

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Influenza virus polymerase basic protein 1 interacts with influenza virus polymerase basic protein 2 at multiple sites.

29 September 2017

1 reference

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Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunit

29 September 2017

1 reference

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Evaluation of the genetic stability of the temperature-sensitive PB2 gene mutation of the influenza A/Ann Arbor/6/60 cold-adapted vaccine virus.

29 September 2017

1 reference

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Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro

29 September 2017

1 reference

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Two of the three influenza viral polymerase proteins expressed by using baculovirus vectors form a complex in insect cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2699363

Determination of influenza virus proteins required for genome replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2699363

Complex formation between influenza virus polymerase proteins expressed in Xenopus oocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2699363

Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding

2 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.138

Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.138

Functional domains of the influenza A virus PB2 protein: identification of NP- and PB1-binding sites

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMBOJ.2009.138

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19461581

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2009.138

1 reference

2206487

2206487

1 reference

1 reference

1 reference