Inflammation and pancreatic cancer: disease promoter and new therapeutic target (Q38167608)

30 August 2017

Inflammation and pancreatic cancer: disease promoter and new therapeutic target (English)

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30 August 2017

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Atsushi Masamune

2

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Tooru Shimosegawa

series ordinal

3

object named as

Tooru Shimosegawa

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30 August 2017

Shin Hamada

1

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30 August 2017

30 November 2013

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Journal of Gastroenterology

30 August 2017

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30 August 2017

49

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30 August 2017

4

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30 August 2017

605-617

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Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation

30 August 2017

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Causes of and prevention strategies for hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

The epidemiology of pancreatitis and pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Do genetic variants in the SPINK1 gene affect the level of serum PSTI?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Familial pancreatic cancer and hereditary syndromes: screening strategy for high-risk individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Diagnosis of pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Cancer. Breaching the cancer fortress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

StellaTUM: current consensus and discussion on pancreatic stellate cell research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Signal transduction in pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hepatic stellate cells in liver development, regeneration, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic stellate cells--multi-functional cells in the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Myeloid-derived suppressor cells: linking inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Immune suppression by tumor-specific CD4+ regulatory T-cells in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

The development of allergic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hypoxia-induced aggressiveness of pancreatic cancer cells is due to increased expression of VEGF, IL-6 and miR-21, which can be attenuated by CDF treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

miR-210 regulates the interaction between pancreatic cancer cells and stellate cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Angiotensin II type 1 receptor interaction is an important regulator for the development of pancreatic fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

A c-Jun NH2-terminal kinase inhibitor SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one) blocks activation of pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic stellate cell migration: role of the phosphatidylinositol 3-kinase(PI3-kinase) pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

NADPH oxidase and apoptosis in cerulein-stimulated pancreatic acinar AR42J cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hedgehog signaling in development and homeostasis of the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hedgehog signaling in the normal and diseased pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Sonic hedgehog promotes desmoplasia in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

A novel integrin alpha5beta1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Cancer-associated stromal fibroblasts promote pancreatic tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic stellate cells: partners in crime with pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Role of pancreatic stellate cells in pancreatic cancer metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Bone morphogenetic protein 4 induces epithelial-mesenchymal transition through MSX2 induction on pancreatic cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Gastrointestinal stem cells in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic cancer stem cell biology and its therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic cancer stem cells: new insights and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Identification of pancreatic cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Japan Pancreatic Cancer Registry; 30th year anniversary: Japan Pancreas Society

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Small-molecule modulators of the Sonic Hedgehog signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Green tea polyphenol epigallocatechin-3-gallate blocks PDGF-induced proliferation and migration of rat pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Ellagic acid blocks activation of pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Curcumin blocks activation of pancreatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Involvement of angiotensin II and reactive oxygen species in pancreatic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

The angiotensin II type I receptor blocker olmesartan inhibits the growth of pancreatic cancer by targeting stellate cell activities in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Stromal disrupting effects of nab-paclitaxel in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Equilibrium between host and cancer caused by effector T cells killing tumor stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

The role of interleukin-12 on modulating myeloid-derived suppressor cells, increasing overall survival and reducing metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00535-013-0915-X

Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice

21 January 2018

1 reference

12 December 2020

Externally applied pressure activates pancreatic stellate cells through the generation of intracellular reactive oxygen species

1 reference

12 December 2020

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta

1 reference

12 December 2020

Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation

1 reference

12 December 2020

CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer

1 reference

12 December 2020

Molecular signatures of pancreatic cancer

1 reference

12 December 2020

Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis

1 reference

12 December 2020

Hypoxia-inducible factor-1alpha regulates matrix metalloproteinase-1 activity in human bone marrow-derived mesenchymal stem cells

1 reference

12 December 2020

Prognostic significance of mast cell count following curative resection for pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Stromal SPARC expression and patient survival after chemoradiation for non-resectable pancreatic adenocarcinoma

1 reference

12 December 2020

10.1007/S00535-013-0915-X

Identifiers

DOI

1 reference

30 August 2017

1 reference

PubMed ID

24292163