Pulmonary arterial hypertension: challenges in translational research and a vision for change (Q38155079)

29 August 2017

Pulmonary arterial hypertension: challenges in translational research and a vision for change (English)

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29 August 2017

arterial hypertension

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author name string

Gopinath Sutendra

series ordinal

1

1 reference

PubMed ID

24154604

29 August 2017

Evangelos D Michelakis

series ordinal

2

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PubMed ID

24154604

29 August 2017

language of work or name

English

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publication date

1 October 2013

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Science Translational Medicine

29 August 2017

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29 August 2017

5

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29 August 2017

208

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29 August 2017

208sr5

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An epidemiological study of pulmonary arterial hypertension.

29 August 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American Co

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Prevalence of HIV-related pulmonary arterial hypertension in the current antiretroviral therapy era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nationwide prospective multicenter study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Updated clinical classification of pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Survival in patients with primary pulmonary hypertension. Results from a national prospective registry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Systematic review of trials using vasodilators in pulmonary arterial hypertension: why a new approach is needed

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Treatment patterns and resource utilization and costs among patients with pulmonary arterial hypertension in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Treatment patterns and healthcare system burden of managed care patients with suspected pulmonary arterial hypertension in the United States

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Emerging concepts and translational priorities in pulmonary arterial hypertension

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Sildenafil citrate therapy for pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST).

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Molecular pathogenesis of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Notch3 signaling promotes the development of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Reversal of experimental pulmonary hypertension by PDGF inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Fatty acid oxidation and malonyl-CoA decarboxylase in the vascular remodeling of pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Acute oxygen-sensing mechanisms

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Diversity in mitochondrial function explains differences in vascular oxygen sensing.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Mitochondria in vascular health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Alterations of cellular bioenergetics in pulmonary artery endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Multifaceted roles of glycolytic enzymes.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Metabolic modulation of glioblastoma with dichloroacetate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

The mitochondrion in apoptosis: how Pandora's box opens

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

NFAT proteins: key regulators of T-cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Activation of the unfolded protein response is associated with pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Insulin resistance in pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Expression of human herpesvirus 8 in primary pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

From viral infection to pulmonary arterial hypertension: a role for viral proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

PGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Inflammation in pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Modern age pathology of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Prognosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Treatment of pulmonary hypertension secondary to connective tissue diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Lung mast cells in plexogenic pulmonary arteriopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Pulmonary arterial remodeling induced by a Th2 immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A role for mitochondria in NLRP3 inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Aerobic glycolysis: meeting the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Mutations in the G6PC3 gene cause Dursun syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Percutaneous pulmonary endoarterial biopsy in an experimental model of pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Apoptosis imaging: beyond annexin V.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Late gadolinium enhancement cardiovascular magnetic resonance predicts clinical worsening in patients with pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Endothelin axis is upregulated in human and rat right ventricular hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Benefits of intensive treadmill exercise training on cardiorespiratory function and quality of life in patients with pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Two-stage model-based clinical trial design to optimize phase I development of novel anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Statistical challenges in the evaluation of treatments for small patient populations

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Metabolic analysis of 13C-labeled pyruvate for noninvasive assessment of mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Future of clinical trials for pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

What is pulmonary arterial hypertension?

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Pathobiology of pulmonary arterial hypertension and right ventricular failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

The Thrombolysis in Myocardial Infarction (TIMI) Study Group experience.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A national cancer clinical trials system for targeted therapies

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A National Cancer Clinical Trials Network: recommendations from the Institute of Medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Pulmonary vascular disease in the developing world.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

A global pulmonary arterial hypertension registry: is it needed? Is it feasible? Pulmonary vascular disease: the global perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Do Changes of 6-Minute Walk Distance Predict Clinical Events in Patients With Pulmonary Arterial Hypertension?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Systemic Inflammation, COPD, and Pulmonary Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

CX3C Chemokine Fractalkine in Pulmonary Arterial Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3005428

10.1126/SCITRANSLMED.3005428

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

24154604