Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer (Q24652941)

British Journal of Cancer

inferred from abstract

1 reference

7 November 2019

1 reference

8 February 2021

E D Michelakis

1

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L Webster

series ordinal

2

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J R Mackey

series ordinal

3

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language of work or name

English

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publication date

7 October 2008

3 references

3 April 2019

7 November 2019

8 February 2021

3 references

3 April 2019

7 November 2019

8 February 2021

99

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page(s)

989-94

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issue

7

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cites work

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Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

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Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial

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Why do cancers have high aerobic glycolysis?

7 April 2017

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Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs

7 April 2017

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Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

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Mitochondrial Membrane Potential in Living Cells

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

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Akt stimulates aerobic glycolysis in cancer cells

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Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation

7 April 2017

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Dichloroacetate induces apoptosis in endometrial cancer cells.

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Cancer's molecular sweet tooth and the Warburg effect.

28 September 2017

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Multifaceted roles of glycolytic enzymes.

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Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

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Efficacy of dichloroacetate as a lactate-lowering drug

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Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.

28 November 2018

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Effects of dichloroacetate infusion on human skeletal muscle metabolism at the onset of exercise

28 November 2018

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PubMed

12 December 2020

1 reference

12 December 2020

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

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PubMed

12 December 2020

Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/SJ.BJC.6604554

1 reference

Dimensions Publication ID

615187

1010689691

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615187

1 reference

1 reference

1 reference