Post-translational modifications and the Warburg effect (Q38149735)

29 August 2017

title

Post-translational modifications and the Warburg effect (English)

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29 August 2017

T Hitosugi

1

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29 August 2017

J Chen

series ordinal

2

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29 August 2017

language of work or name

English

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publication date

7 October 2013

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29 August 2017

number of pages

7

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based on heuristic

inferred from page(s)

published in

Oncogene

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29 August 2017

volume

33

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29 August 2017

issue

34

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29 August 2017

page(s)

4279-4285

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https://scigraph.springernature.com/pub.10.1038/onc.2013.406

29 August 2017

exact match

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cites work

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

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Oncogenic kinase signalling

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A census of human cancer genes

21 January 2018

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Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus

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Four Different Classes of Retroviruses Induce Phosphorylation of Tyrosines Present in Similar Cellular Proteins

21 January 2018

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Protein kinase B stimulates the translocation of GLUT4 but not GLUT1 or transferrin receptors in 3T3-L1 adipocytes by a pathway involving SNAP-23, synaptobrevin-2, and/or cellubrevin

21 January 2018

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A role for protein kinase Bbeta/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes

21 January 2018

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

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Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin

21 January 2018

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Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

21 January 2018

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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

21 January 2018

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Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

21 January 2018

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Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

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Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

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Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II.

21 January 2018

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Phosphofructokinase 1 glycosylation regulates cell growth and metabolism

21 January 2018

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Mechanism of the 2,3-diphosphoglycerate-dependent phosphoglycerate mutase from rabbit muscle

21 January 2018

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Influence of salt, substrate, and cofactor concentrations on the kinetic and mechanistic behavior of phosphoglycerate mutase

21 January 2018

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Metabolic transformation in cancer.

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Targeting metabolic transformation for cancer therapy.

21 January 2018

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Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation

21 January 2018

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Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation

21 January 2018

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Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides

21 January 2018

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Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

21 January 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 January 2018

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

21 January 2018

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

21 January 2018

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Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.

21 January 2018

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

21 January 2018

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Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

21 January 2018

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PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Pharmacologic activation of PKM2 slows lung tumor xenograft growth.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer

21 January 2018

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SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

Metabolic modulation of glioblastoma with dichloroacetate

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Hypoxia signalling controls metabolic demand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

The role of p53 in glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

Tumor cell metabolism: cancer's Achilles' heel

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.406

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

Recombinant human phenylalanine hydroxylase is a substrate for the ubiquitin-conjugating enzyme system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

Proteomic approaches to the characterization of protein thiol modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

The use of mass spectrometry for the proteomic analysis of glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

Glucose transporters: expression, regulation and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

The regulation of energy generating metabolic pathways by p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.406

31 March 2020

Identifiers

DOI

10.1038/ONC.2013.406

1 reference

Dimensions Publication ID

29 August 2017

1050168276

0 references

1 reference