Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. (Q46862539)

25 December 2017

title

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II. (English)

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25 December 2017

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25 December 2017

author name string

Miyamoto S

series ordinal

1

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25 December 2017

Brown JH

series ordinal

3

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25 December 2017

publication date

7 December 2007

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25 December 2017

Cell Death & Differentiation

published in

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25 December 2017

volume

15

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25 December 2017

issue

3

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25 December 2017

page(s)

521-529

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25 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402285

exact match

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cites work

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Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

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Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT.

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Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury

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Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

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Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution

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Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death

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Elevated expression of hexokinase II protects human lung epithelial-like A549 cells against oxidative injury

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RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis

21 January 2018

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Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro

21 January 2018

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7 January 2021

Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity

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7 January 2021

Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation

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7 January 2021

VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402285

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25 December 2017

PubMed ID

18064042

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25 December 2017