Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology (Q38141512)

29 August 2017

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology (English)

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29 August 2017

2

Ruth H Palmer

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29 August 2017

1

Bengt Hallberg

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PubMed ID

24060861

29 August 2017

language of work or name

English

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publication date

1 October 2013

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29 August 2017

Nature Reviews Cancer

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29 August 2017

13

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29 August 2017

685-700

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29 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrc3580

29 August 2017

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cites work

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

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Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

31 March 2020

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Anaplastic lymphoma kinase as a therapeutic target.

31 March 2020

1 reference

Inhibition of ALK signaling for cancer therapy

31 March 2020

1 reference

Anaplastic lymphoma kinase: signalling in development and disease

31 March 2020

1 reference

Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin

31 March 2020

1 reference

Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types

31 March 2020

1 reference

Midkine and pleiotrophin in neural development and cancer

31 March 2020

1 reference

Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis

31 March 2020

1 reference

Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation

31 March 2020

1 reference

In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)?

31 March 2020

1 reference

Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.

31 March 2020

1 reference

ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

31 March 2020

1 reference

Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.

31 March 2020

1 reference

Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma

31 March 2020

1 reference

Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer

31 March 2020

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Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer.

31 March 2020

1 reference

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

31 March 2020

1 reference

CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study

31 March 2020

1 reference

ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction.

31 March 2020

1 reference

Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system

31 March 2020

1 reference

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

31 March 2020

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Characterization of the expression of the ALK receptor tyrosine kinase in mice

31 March 2020

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Cooperative Cross-Talk between Neuroblastoma Subtypes Confers Resistance to Anaplastic Lymphoma Kinase Inhibition

31 March 2020

1 reference

Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications

31 March 2020

1 reference

An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol

31 March 2020

1 reference

Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.

31 March 2020

1 reference

An SCF-like ubiquitin ligase complex that controls presynaptic differentiation

31 March 2020

1 reference

C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling

31 March 2020

1 reference

A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster

31 March 2020

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Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish

31 March 2020

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Leukocyte tyrosine kinase functions in pigment cell development

31 March 2020

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Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.

31 March 2020

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Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers.

31 March 2020

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Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(mili(Alk)) as receptor for Jeb signalling.

31 March 2020

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Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation.

31 March 2020

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HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans

31 March 2020

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Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila.

31 March 2020

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Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap.

31 March 2020

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The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning

31 March 2020

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Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila.

31 March 2020

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Drosophila Anaplastic Lymphoma Kinase regulates Dpp signalling in the developing embryonic gut.

31 March 2020

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High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

31 March 2020

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Oncogenic mutations of ALK kinase in neuroblastoma

31 March 2020

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

31 March 2020

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Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

31 March 2020

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Identification of ALK as a major familial neuroblastoma predisposition gene

31 March 2020

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Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.

31 March 2020

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Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684.

31 March 2020

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Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

31 March 2020

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A Simple, Highly Visual in Vivo Screen for Anaplastic Lymphoma Kinase Inhibitors

31 March 2020

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Cell signaling by receptor tyrosine kinases

31 March 2020

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Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells

31 March 2020

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Anaplastic lymphoma kinase in human cancer

31 March 2020

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The anaplastic lymphoma kinase in the pathogenesis of cancer

31 March 2020

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Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA)

31 March 2020

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NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry

31 March 2020

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The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation

31 March 2020

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Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.

31 March 2020

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p130Cas mediates the transforming properties of the anaplastic lymphoma kinase

31 March 2020

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Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity

31 March 2020

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The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic Lymphoma Cell Growth and Migration

31 March 2020

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The tyrosine 343 residue of nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) is important for its interaction with SHP1, a cytoplasmic tyrosine phosphatase with tumor suppressor functions

31 March 2020

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The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness

31 March 2020

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The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.

31 March 2020

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Identification of NPM-ALK interacting proteins by tandem mass spectrometry.

31 March 2020

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Proteomic analysis of anaplastic lymphoma cell lines: identification of potential tumour markers.

31 March 2020

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NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma

31 March 2020

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The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways.

31 March 2020

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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

31 March 2020

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Global proteome profiling of NPM/ALK-positive anaplastic large cell lymphoma.

31 March 2020

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Proteome-wide identification of novel binding partners to the oncogenic fusion gene protein, NPM-ALK, using tandem affinity purification and mass spectrometry

31 March 2020

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Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein

31 March 2020

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Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.

31 March 2020

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Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells

31 March 2020

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Oncogenic kinase NPM/ALK induces expression of HIF1α mRNA.

31 March 2020

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The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling

31 March 2020

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Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas.

31 March 2020

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MiR-29a down-regulation in ALK-positive anaplastic large cell lymphomas contributes to apoptosis blockade through MCL-1 overexpression

31 March 2020

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miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.

31 March 2020

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MicroRNA 96 is a post-transcriptional suppressor of anaplastic lymphoma kinase expression

31 March 2020

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Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: a success story to usher in the second decade of molecular targeted therapy in oncology

31 March 2020

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Pathobiology of ALK+ anaplastic large-cell lymphoma

31 March 2020

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Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor

31 March 2020

1 reference

ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35).

31 March 2020

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Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity

31 March 2020

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Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma

31 March 2020

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Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4--anaplastic lymphoma kinase gene fusion

31 March 2020

1 reference

Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma

31 March 2020

1 reference

TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors

31 March 2020

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Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor

31 March 2020

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RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors.

31 March 2020

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Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor

31 March 2020

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ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor

31 March 2020

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Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor

31 March 2020

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Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification

31 March 2020

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Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor

31 March 2020

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Pediatric inflammatory myofibroblastic tumor: anaplastic lymphoma kinase (ALK) expression and prognosis

31 March 2020

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ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project

31 March 2020

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[Cytomorphology and molecular characterization of CLTC-ALK rearrangement in 2 cases of ALK-positive diffuse large B-cell lymphoma with extensive bone marrow involvement].

31 March 2020

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ALK-positive diffuse large B-cell lymphoma: report of three cases

31 March 2020

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Hyperactivated STAT3 in ALK-positive diffuse large B-cell lymphoma with clathrin-ALK fusion

31 March 2020

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ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature

31 March 2020

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Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3' ALK gene insertion to chromosome 4 q22-24

31 March 2020

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ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.

31 March 2020

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A Case of a Diffuse Large B-Cell Lymphoma of Plasmablastic Type Associated With the t(2;5)(p23;q35) Chromosome Translocation

31 March 2020

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ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases

31 March 2020

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Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma.

31 March 2020

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ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions

31 March 2020

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Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival

31 March 2020

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Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling

31 March 2020

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

31 March 2020

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Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer

31 March 2020

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Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing

31 March 2020

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KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer

31 March 2020

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KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only

31 March 2020

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Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing

31 March 2020

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Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK

31 March 2020

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Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.

31 March 2020

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Renal cell carcinoma with novel VCL-ALK fusion: new representative of ALK-associated tumor spectrum

31 March 2020

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Identification of anaplastic lymphoma kinase fusions in renal cancer: large-scale immunohistochemical screening by the intercalated antibody-enhanced polymer method.

31 March 2020

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ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients

31 March 2020

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Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers

31 March 2020

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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

31 March 2020

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Identification of anaplastic lymphoma kinase as a potential therapeutic target in ovarian cancer

31 March 2020

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Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma

31 March 2020

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Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer

31 March 2020

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Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases

31 March 2020

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The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination

31 March 2020

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Expression and functional analysis of the anaplastic lymphoma kinase (ALK) gene in tumor cell lines

31 March 2020

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Expression of the ALK tyrosine kinase gene in neuroblastoma

31 March 2020

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Domain-specific function of ShcC docking protein in neuroblastoma cells

31 March 2020

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Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines

31 March 2020

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Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients

31 March 2020

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Increased ALK gene copy number and amplification are frequent in non-small cell lung cancer

31 March 2020

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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

31 March 2020

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Overall genomic pattern is a predictor of outcome in neuroblastoma

31 March 2020

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Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma

31 March 2020

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EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

31 March 2020

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Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene

31 March 2020

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Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma.

31 March 2020

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Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer.

31 March 2020

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The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers

31 March 2020

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31 March 2020

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Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

31 March 2020

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The neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo

31 March 2020

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Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

31 March 2020

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Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.

31 March 2020

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Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

31 March 2020

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The genetic landscape of high-risk neuroblastoma

31 March 2020

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Recent advances in neuroblastoma

31 March 2020

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ArrayCGH-based classification of neuroblastoma into genomic subgroups

31 March 2020

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Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma

31 March 2020

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High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma

31 March 2020

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Protein kinase signaling networks in cancer

31 March 2020

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Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.

31 March 2020

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Myc proteins as therapeutic targets

31 March 2020

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Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.

31 March 2020

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ALK and MYCN: when two oncogenes are better than one.

31 March 2020

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The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma

31 March 2020

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Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.

31 March 2020

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Tumor development, growth characteristics and spectrum of genetic aberrations in the TH-MYCN mouse model of neuroblastoma

31 March 2020

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NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

31 March 2020

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The significance of unstable chromosomes in colorectal cancer.

31 March 2020

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Cancer genes and the pathways they control

31 March 2020

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Diagnostic assays for identification of anaplastic lymphoma kinase-positive non-small cell lung cancer

31 March 2020

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Treatment of non-small-cell lung cancer with erlotinib or gefitinib

31 March 2020

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Crizotinib--latest champion in the cancer wars?

31 March 2020

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ALK and NSCLC: Targeted therapy with ALK inhibitors

31 March 2020

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Combinatorial drug therapy for cancer in the post-genomic era.

31 March 2020

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Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

31 March 2020

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Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

31 March 2020

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The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models

31 March 2020

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Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer

31 March 2020

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Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study.

31 March 2020

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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

31 March 2020

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A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors

31 March 2020

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Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

31 March 2020

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Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors

31 March 2020

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Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain

31 March 2020

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Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

31 March 2020

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Targeting ALK in neuroblastoma--preclinical and clinical advancements

31 March 2020

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Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma

31 March 2020

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The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase

31 March 2020

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Characterization of some molecular mechanisms governing autoactivation of the catalytic domain of the anaplastic lymphoma kinase.

31 March 2020

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Defining the conserved internal architecture of a protein kinase.

31 March 2020

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A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function.

31 March 2020

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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

31 March 2020

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Involvement of genes required for synaptic function in aging control in C. elegans

31 March 2020

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Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans.

31 March 2020

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Insulin-like signaling and the neural circuit for integrative behavior in C. elegans

31 March 2020

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Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans.

31 March 2020

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Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo

31 March 2020

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The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut.

31 March 2020

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Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture.

31 March 2020

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ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome

31 March 2020

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Assessment of the transforming potential of novel anaplastic lymphoma kinase point mutants

31 March 2020

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ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

31 March 2020

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Suppressors of transforming growth factor-beta pathway mutants in the Caenorhabditis elegans dauer formation pathway

31 March 2020

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12 December 2020

CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features

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12 December 2020

Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like)

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12 December 2020

TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations

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12 December 2020

Zebrafish pigmentation mutations and the processes of neural crest development.

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12 December 2020

Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors

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12 December 2020

Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma.

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12 December 2020

NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma

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12 December 2020

A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation

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12 December 2020

Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity.

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12 December 2020

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12 December 2020

Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis

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12 December 2020

Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3

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12 December 2020

ALK+ lymphoma: clinico-pathological findings and outcome.

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12 December 2020

Complex variant translocation t(1;2) with TPM3-ALK fusion due to cryptic ALK gene rearrangement in anaplastic large-cell lymphoma

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12 December 2020

Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1

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12 December 2020

Identifiers

DOI

10.1038/NRC3580

1 reference

PubMed ID

24060861

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

24060861