Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF (Q24298749)

V-raf-leukemia viral oncogene 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

6

Nathalie Dhomen

Nathalie

Dhomen

1 reference

19 October 2023

3

Steven Whittaker

Steven

Whittaker

1 reference

19 October 2023

11

Richard Marais

Richard

Marais

1 reference

19 October 2023

Caroline J Springer

9

Caroline J

Springer

1 reference

19 October 2023

Catrin Pritchard

10

Catrin

Pritchard

1 reference

19 October 2023

8

Jorge S Reis-Filho

Jorge S

Reis-Filho

1 reference

19 October 2023

Sonja J Heidorn

1

Sonja J

Heidorn

1 reference

19 October 2023

Carla Milagre

2

Carla

Milagre

1 reference

19 October 2023

Arnaud Nourry

4

Arnaud

Nourry

1 reference

19 October 2023

Ion Niculescu-Duvas

5

Ion

Niculescu-Duvas

1 reference

19 October 2023

Jahan Hussain

7

Jahan

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Hussain

1 reference

19 October 2023

language of work or name

English

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publication date

22 January 2010

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published in

Cell

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volume

140

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page(s)

209-21

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issue

2

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cites work

1 reference

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

19 March 2017

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

A dimerization-dependent mechanism drives RAF catalytic activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Regulation and role of Raf-1/B-Raf heterodimerization

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

19 March 2017

1 reference

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Guilty as charged: B-RAF is a human oncogene

19 March 2017

1 reference

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Active Ras induces heterodimerization of cRaf and BRaf

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Inhibitor hijacking of Akt activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Oncogenic Braf induces melanocyte senescence and melanoma in mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Therapeutic strategies for inhibiting oncogenic BRAF signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Melanoma biology and new targeted therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Paradoxical activation of Raf by a novel Raf inhibitor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Inhibitors paradoxically prime kinases.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Spatiotemporal gene control by the Cre-ERT2 system in melanocytes.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2872605

UKCCCR guidelines for the welfare of animals in experimental neoplasia

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20141835

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2009.12.040

1 reference

release_7tcepszaqbbolg36qq2x6mqmki

867339

Fatcat ID

0 references

867339

1 reference

1 reference

1 reference