Autophagy in chronic myeloid leukaemia: stem cell survival and implication in therapy (Q38128600)

29 August 2017

Autophagy in chronic myeloid leukaemia: stem cell survival and implication in therapy (English)

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29 August 2017

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Tessa L Holyoake

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G. Vignir Helgason

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Gudmundur V Helgason

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29 August 2017

Arunima Mukhopadhyay

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29 August 2017

Maria Karvela

3

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29 August 2017

Paolo Salomoni

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29 August 2017

Bruno Calabretta

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29 August 2017

1 September 2013

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Current Cancer Drug Targets

29 August 2017

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29 August 2017

724-734

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29 August 2017

Functions of lysosomes

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12 December 2020

Osteoblastic cells regulate the haematopoietic stem cell niche

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12 December 2020

The origin of the autophagosomal membrane

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12 December 2020

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent

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12 December 2020

Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

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12 December 2020

The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells

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12 December 2020

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

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12 December 2020

Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

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12 December 2020

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

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12 December 2020

Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606.

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12 December 2020

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

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12 December 2020

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

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12 December 2020

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

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12 December 2020

Principles and current strategies for targeting autophagy for cancer treatment

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12 December 2020

Mitochondria supply membranes for autophagosome biogenesis during starvation

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12 December 2020

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

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12 December 2020

A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche

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12 December 2020

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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12 December 2020

Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia

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12 December 2020

Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.

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12 December 2020

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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12 December 2020

Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML.

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12 December 2020

Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis.

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12 December 2020

Targeted therapies and autophagy: new insights from chronic myeloid leukemia

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12 December 2020

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

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12 December 2020

The role of the Atg1/ULK1 complex in autophagy regulation

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12 December 2020

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells

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12 December 2020

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

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12 December 2020

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

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12 December 2020

Autophagy suppresses tumor progression by limiting chromosomal instability

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12 December 2020

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series

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12 December 2020

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

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12 December 2020

Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells

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12 December 2020

Hydroxychloroquine for chronic myeloid leukemia: complete cure on the horizon?

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12 December 2020

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

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12 December 2020

Development by self-digestion: molecular mechanisms and biological functions of autophagy

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12 December 2020

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

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12 December 2020

Autophagy: basic principles and relevance to disease

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12 December 2020

Plasma membrane contributes to the formation of pre-autophagosomal structures

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12 December 2020

The role of autophagy in tumour development and cancer therapy.

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12 December 2020

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

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12 December 2020

Identification of the haematopoietic stem cell niche and control of the niche size

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12 December 2020

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

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12 December 2020

Autophagy in metazoans: cell survival in the land of plenty

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12 December 2020

Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors

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12 December 2020

Guidelines for the use and interpretation of assays for monitoring autophagy

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12 December 2020

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

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12 December 2020

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

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12 December 2020

Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo

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12 December 2020

A new purpose for an old drug: inhibiting autophagy with clarithromycin.

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12 December 2020

Hematopoiesis: an evolving paradigm for stem cell biology

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12 December 2020

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.

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12 December 2020

Chromosome studies on normal and leukemic human leukocytes

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12 December 2020

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

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12 December 2020

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

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12 December 2020

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants

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12 December 2020

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

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12 December 2020

Nonredundant role of Atg7 in mitochondrial clearance during erythroid development.

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12 December 2020

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

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12 December 2020

Clarithromycin enhances dasatinib-induced cell death in chronic myeloid leukemia cells, by inhibition of late stage autophagy

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12 December 2020

A dual role of p53 in the control of autophagy

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12 December 2020

Ambra1 at the crossroad between autophagy and cell death

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12 December 2020

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

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12 December 2020

Role for Rab7 in maturation of late autophagic vacuoles

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12 December 2020

The role of autophagy in clinical practice

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12 December 2020

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

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12 December 2020

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells.

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12 December 2020

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

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12 December 2020

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

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12 December 2020

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

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12 December 2020

Inhibition of autophagy: a new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors

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12 December 2020

Maintenance of genomic integrity in hematopoietic stem cells

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12 December 2020

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

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12 December 2020

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

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12 December 2020

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

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12 December 2020

Clarithromycin potentiates tyrosine kinase inhibitor treatment in patients with resistant chronic myeloid leukemia

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12 December 2020

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

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12 December 2020

Autophagy modulation as a potential therapeutic target for diverse diseases

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12 December 2020

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

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12 December 2020

PML targeting eradicates quiescent leukaemia-initiating cells

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12 December 2020

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.

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12 December 2020

The role of autophagy in cancer: therapeutic implications

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12 December 2020

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

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12 December 2020

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

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12 December 2020

Autophagosome formation: core machinery and adaptations

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12 December 2020

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

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12 December 2020

p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.

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12 December 2020

Induction of autophagy and inhibition of tumorigenesis by beclin 1

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12 December 2020

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

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12 December 2020

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

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12 December 2020

Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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12 December 2020

Staying alive: metabolic adaptations to quiescence

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12 December 2020

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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12 December 2020

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

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12 December 2020

Molecular dissection of autophagy: two ubiquitin-like systems

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12 December 2020

A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell

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12 December 2020

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

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12 December 2020

Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells

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12 December 2020

FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system

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12 December 2020

Role of autophagy in cancer

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12 December 2020

An overview of the molecular mechanism of autophagy

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12 December 2020

Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin

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12 December 2020

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

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12 December 2020

BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription

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12 December 2020

The double-edged sword of autophagy modulation in cancer

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12 December 2020

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

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12 December 2020

10.2174/15680096113139990088

Identifiers

DOI

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release_imw432pevbgjtpnnidxkkhkzou

29 August 2017

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https://api.fatcat.wiki/v0/release/imw432pevbgjtpnnidxkkhkzou

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