Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival (Q35776432)

10 August 2017

title

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival (English)

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10 August 2017

main subject

chronic myeloid leukemia

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1 reference

11

Steffen Koschmieder

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Carsten Müller-Tidow

8

Carsten Müller-Tidow

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Svetlana Myssina

Svetlana Myssina

5

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G. Vignir Helgason

G Vignir Helgason

2

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Tessa Holyoake

Tessa L Holyoake

12

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Valerie G Brunton

10

Valerie G Brunton

1 reference

10 August 2017

Ashley Hamilton

1

1 reference

10 August 2017

Mirle Schemionek

3

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10 August 2017

Bin Zhang

4

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10 August 2017

Elaine K Allan

6

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10 August 2017

Franck E Nicolini

7

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10 August 2017

Ravi Bhatia

9

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10 August 2017

language of work or name

English

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publication date

19 December 2011

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10 August 2017

number of pages

10

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inferred from page(s)

published in

Blood

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10 August 2017

volume

119

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10 August 2017

issue

6

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10 August 2017

page(s)

1501-1510

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Assembling defenses against therapy-resistant leukemic stem cells: Bcl6 joins the ranks

10 August 2017

cites work

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27 July 2018

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BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

27 July 2018

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Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease

27 July 2018

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Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

27 July 2018

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In search of the original leukemic clone in chronic myeloid leukemia patients in complete molecular remission after stem cell transplantation or imatinib.

27 July 2018

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BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

27 July 2018

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Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

27 July 2018

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Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients

27 July 2018

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Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis

27 July 2018

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Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells

27 July 2018

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27 July 2018

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27 July 2018

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A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

27 July 2018

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Janus kinase 2: a critical target in chronic myelogenous leukemia

27 July 2018

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27 July 2018

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Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate

27 July 2018

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BCR-ABL activity and its response to drugs can be determined in CD34+ CML stem cells by CrkL phosphorylation status using flow cytometry.

27 July 2018

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Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results

27 July 2018

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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

27 July 2018

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27 July 2018

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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

27 July 2018

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Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.

27 July 2018

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

27 July 2018

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27 July 2018

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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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25 September 2018

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25 September 2018

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Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells

25 September 2018

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Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

Assessment and follow-up of the proportion of T315I mutant BCR-ABL transcripts can guide appropriate therapeutic decision making in CML patients

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

Specific killing of Ph+ chronic myeloid leukemia cells by a lentiviral vector-delivered anti-bcr/abl small hairpin RNA.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286213

High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations

6 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22184410

12 December 2020

inferred from PubMed ID database lookup

OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22184410

12 December 2020

inferred from PubMed ID database lookup

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22184410

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1182/BLOOD-2010-12-326843

1 reference

10 August 2017

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10 August 2017

1 reference