The multifaceted role of glial cells in amyotrophic lateral sclerosis (Q38126396)

29 August 2017

The multifaceted role of glial cells in amyotrophic lateral sclerosis (English)

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amyotrophic lateral sclerosis

29 August 2017

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Francesca Martorana

3

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Liliana Brambilla

object named as

Liliana Brambilla

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2

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Daniela Rossi

object named as

Daniela Rossi

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4

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author name string

Chiara F Valori

series ordinal

1

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PubMed ID

23912896

29 August 2017

language of work or name

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3 August 2013

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Cellular and Molecular Life Sciences

29 August 2017

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29 August 2017

71

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29 August 2017

287-297

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29 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s00018-013-1429-7

29 August 2017

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cites work

Clinical diagnosis and management of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Mutations of optineurin in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Neuroscience: Glia — more than just brain glue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Implications of gliotransmission for the pharmacotherapy of CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Glial cells in (patho)physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Intricate interplay between astrocytes and motor neurons in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

D-amino acid oxidase controls motoneuron degeneration through D-serine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Focal degeneration of astrocytes in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astrocytes and disease: a neurodevelopmental perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Heterogeneity of astrocytic form and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Microglia: scapegoat, saboteur, or something else?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Onset and progression in inherited ALS determined by motor neurons and microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Oligodendroglia metabolically support axons and contribute to neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Adult glial precursor proliferation in mutant SOD1G93A mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Regulation of oligodendrocyte development and myelination by glucose and lactate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Distinct pathological subtypes of FTLD-FUS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

A novel double mutation in FUS gene causing sporadic ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

A Japanese ALS6 family with mutation R521C in the FUS/TLS gene: a clinical, pathological and genetic report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Novel heterozygous nonsense mutation of the OPTN gene segregating in a Danish family with ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Identification of a transcription factor IIIA-interacting protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin/Rab8 complex from the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Ubiquitination and selective autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astroglia in dementia and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Astrocytic cytoskeletal atrophy in the medial prefrontal cortex of a triple transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Gliogenesis and glial pathology in depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

The BH4 domain of Bcl-XL rescues astrocyte degeneration in amyotrophic lateral sclerosis by modulating intracellular calcium signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Novel optineurin mutations in sporadic amyotrophic lateral sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-013-1429-7

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

21 January 2018

1 reference

12 December 2020

NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions.

1 reference

12 December 2020

TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia

1 reference

12 December 2020

Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions

1 reference

12 December 2020

Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis

1 reference

12 December 2020

Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration

1 reference

12 December 2020

Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells

1 reference

12 December 2020

Changes in the myelinated axons of femoral nerve in amyotrophic lateral sclerosis.

1 reference

12 December 2020

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

1 reference

12 December 2020

Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease

1 reference

12 December 2020

Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis

1 reference

12 December 2020

Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF

1 reference

12 December 2020

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue

1 reference

12 December 2020

Expression of ubiquitin and proteasome in motorneurons and astrocytes of spinal cords from patients with amyotrophic lateral sclerosis

1 reference

12 December 2020

Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice

1 reference

12 December 2020

Aggregates of mutant protein appear progressively in dendrites, in periaxonal processes of oligodendrocytes, and in neuronal and astrocytic perikarya of mice expressing the SOD1(G93A) mutation of familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD

1 reference

12 December 2020

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.

1 reference

12 December 2020

Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease.

1 reference

12 December 2020

Nuclear factor κ B expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations

1 reference

12 December 2020

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.

1 reference

12 December 2020

Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis

1 reference

12 December 2020

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

1 reference

12 December 2020

10.1007/S00018-013-1429-7

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

23912896