Epigenetic profiling joins personalized cancer medicine (Q38115623)

29 August 2017

Epigenetic profiling joins personalized cancer medicine (English)

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29 August 2017

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29 August 2017

Holger Heyn

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Jesús Méndez-González

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2

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29 August 2017

1 June 2013

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Expert Review of Molecular Diagnostics: new diagnostic technologies are set to revolutionise healthcare

29 August 2017

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29 August 2017

13

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29 August 2017

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29 August 2017

473-479

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Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing

29 August 2017

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Cancer treatment according to BRCA1 and BRCA2 mutations

21 January 2018

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21 January 2018

Epigenetics in cancer

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A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

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21 January 2018

Epigenetics in cancer

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21 January 2018

The Hallmarks of Cancer

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DNA methylation profiling in the clinic: applications and challenges

21 January 2018

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Cancer epigenetics reaches mainstream oncology

21 January 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

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Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

21 January 2018

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Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

21 January 2018

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Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates

21 January 2018

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Increased methylation variation in epigenetic domains across cancer types

21 January 2018

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DNA methylation dynamics during in vivo differentiation of blood and skin stem cells

21 January 2018

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Cancer epigenomics: DNA methylomes and histone-modification maps

21 January 2018

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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

21 January 2018

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Human DNA methylomes at base resolution show widespread epigenomic differences

21 January 2018

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Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome

21 January 2018

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Genomic distribution and inter-sample variation of non-CpG methylation across human cell types

21 January 2018

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Epigenetic modifications and human disease

21 January 2018

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

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Mapping and analysis of chromatin state dynamics in nine human cell types

21 January 2018

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Relationship between nucleosome positioning and DNA methylation

21 January 2018

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Non-coding RNAs in human disease

21 January 2018

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Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications.

21 January 2018

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Guthrie card methylomics identifies temporally stable epialleles that are present at birth in humans

21 January 2018

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Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

21 January 2018

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

21 January 2018

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Highly integrated single-base resolution maps of the epigenome in Arabidopsis

21 January 2018

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The DNA methylome of human peripheral blood mononuclear cells

21 January 2018

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Distinct DNA methylomes of newborns and centenarians

21 January 2018

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Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

21 January 2018

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Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains

21 January 2018

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Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia.

21 January 2018

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Whole-genome bisulfite DNA sequencing of a DNMT3B mutant patient

21 January 2018

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High density DNA methylation array with single CpG site resolution

21 January 2018

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Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

21 January 2018

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DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer

21 January 2018

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MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

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Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis.

21 January 2018

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A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

21 January 2018

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Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo

21 January 2018

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Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling

21 January 2018

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Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer

21 January 2018

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IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer.

21 January 2018

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Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

21 January 2018

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BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer

21 January 2018

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Integrated genomic analyses of ovarian carcinoma

21 January 2018

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Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

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Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

21 January 2018

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Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells

21 January 2018

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The epigenetic promise for prostate cancer diagnosis

21 January 2018

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DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

21 January 2018

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Prognostic significance of gene-specific promoter hypermethylation in breast cancer patients

21 January 2018

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Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells

21 January 2018

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Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.

21 January 2018

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

21 January 2018

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Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

21 January 2018

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DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients--Technical and clinical validation in a multi-centre setting in collaborati

21 January 2018

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The epidermal growth factor receptor pathway: a model for targeted therapy

21 January 2018

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CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer.

21 January 2018

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First-line therapy and methylation status of CHFR in serum influence outcome to chemotherapy versus EGFR tyrosine kinase inhibitors as second-line therapy in stage IV non-small-cell lung cancer patients

21 January 2018

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Epithelial-mesenchymal transition, cancer stem cells and treatment resistance

21 January 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

21 January 2018

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Systematic identification of genomic markers of drug sensitivity in cancer cells

21 January 2018

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

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Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia

21 January 2018

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BRCA1 CpG Island Hypermethylation Predicts Sensitivity to Poly(Adenosine Diphosphate)- Ribose Polymerase Inhibitors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERM.13.36

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29 August 2017

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PubMed ID

23782254