Harnessing the power of yeast to unravel the molecular basis of neurodegeneration. (Q38100231)

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29 February 2020

title

Harnessing the power of yeast to unravel the molecular basis of neurodegeneration (English)

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29 February 2020

1 reference

1

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29 February 2020

Matthias C Munder

2

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29 February 2020

Simon Alberti

3

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29 February 2020

Tiago Fleming Outeiro

4

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29 February 2020

author name string

Tiago F Outeiro

4

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28 August 2017

language of work or name

English

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publication date

8 May 2013

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Journal of Neurochemistry

29 February 2020

published in

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29 February 2020

volume

127

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29 February 2020

issue

4

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29 February 2020

page(s)

438-452

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Heat shock factors: integrators of cell stress, development and lifespan.

29 February 2020

cites work

1 reference

A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae

21 January 2018

1 reference

A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

21 January 2018

1 reference

A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

21 January 2018

1 reference

Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

21 January 2018

1 reference

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

21 January 2018

1 reference

21 January 2018

TDP-43 toxicity in yeast

1 reference

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models

21 January 2018

1 reference

Isolation of drugs active against mammalian prions using a yeast-based screening assay

21 January 2018

1 reference

A yeast-based assay to isolate drugs active against mammalian prions

21 January 2018

1 reference

Modulation of Abeta42 low-n oligomerization using a novel yeast reporter system

21 January 2018

1 reference

Analysis of amyloid aggregates using agarose gel electrophoresis

21 January 2018

1 reference

Yeast as a model to study mitochondrial mechanisms in ageing.

21 January 2018

1 reference

Yeast as a model for studying Alzheimer's disease.

21 January 2018

1 reference

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases

21 January 2018

1 reference

The mechanisms of vesicle budding and fusion

21 January 2018

1 reference

21 January 2018

1 reference

Retrograde transport from endosomes to the trans-Golgi network

21 January 2018

1 reference

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

21 January 2018

1 reference

Yeast: an experimental organism for 21st Century biology

21 January 2018

1 reference

Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration.

21 January 2018

1 reference

Nervous yeast: modeling neurotoxic cell death

21 January 2018

1 reference

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

21 January 2018

1 reference

Functional mitochondria are required for alpha-synuclein toxicity in aging yeast.

21 January 2018

1 reference

The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease

21 January 2018

1 reference

Considerations for creating and annotating the budding yeast Genome Map at SGD: a progress report

21 January 2018

1 reference

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability.

21 January 2018

1 reference

Cellular strategies of protein quality control

21 January 2018

1 reference

Saccharomyces Genome Database: the genomics resource of budding yeast

21 January 2018

1 reference

The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast

21 January 2018

1 reference

Aggregation of polyQ proteins is increased upon yeast aging and affected by Sir2 and Hsf1: novel quantitative biochemical and microscopic assays

21 January 2018

1 reference

TDP-43 is recruited to stress granules in conditions of oxidative insult.

21 January 2018

1 reference

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

1 reference

Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants

21 January 2018

1 reference

The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog

21 January 2018

1 reference

A yeast functional screen predicts new candidate ALS disease genes

21 January 2018

1 reference

RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations

21 January 2018

1 reference

Protein folding and misfolding

21 January 2018

1 reference

Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions

21 January 2018

1 reference

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.

21 January 2018

1 reference

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

21 January 2018

1 reference

Countering amyloid polymorphism and drug resistance with minimal drug cocktails

21 January 2018

1 reference

A network of protein interactions determines polyglutamine toxicity

21 January 2018

1 reference

Flanking sequences profoundly alter polyglutamine toxicity in yeast

21 January 2018

1 reference

Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans

21 January 2018

1 reference

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

21 January 2018

1 reference

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

21 January 2018

1 reference

CELL BIOLOGY: Whither Model Organism Research?

21 January 2018

1 reference

YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation

21 January 2018

1 reference

Biochemical and genetic analysis of the yeast proteome with a movable ORF collection

21 January 2018

1 reference

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

21 January 2018

1 reference

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

1 reference

Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation.

21 January 2018

1 reference

21 January 2018

1 reference

Polyglutamine toxicity is controlled by prion composition and gene dosage in yeast

21 January 2018

1 reference

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

21 January 2018

1 reference

TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function

21 January 2018

1 reference

A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential

21 January 2018

1 reference

Structure and function of the molecular chaperone Hsp104 from yeast

21 January 2018

1 reference

Development of a novel yeast cell-based system for studying the aggregation of Alzheimer's disease-associated Abeta peptides in vivo.

21 January 2018

1 reference

Prions are a common mechanism for phenotypic inheritance in wild yeasts.

21 January 2018

1 reference

The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists

21 January 2018

1 reference

Altered transcription in yeast expressing expanded polyglutamine

21 January 2018

1 reference

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

21 January 2018

1 reference

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity

21 January 2018

1 reference

Probing the role of structural features of mouse PrP in yeast by expression as Sup35-PrP fusions

21 January 2018

1 reference

Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice

21 January 2018

1 reference

A yeast model of FUS/TLS-dependent cytotoxicity

21 January 2018

1 reference

Saccharomyces cerevisiae as a model organism: a comparative study

21 January 2018

1 reference

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

21 January 2018

1 reference

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

21 January 2018

1 reference

Genetics of Parkinson's disease

21 January 2018

1 reference

Methods for monitoring autophagy from yeast to human

21 January 2018

1 reference

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models

21 January 2018

1 reference

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

21 January 2018

1 reference

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis

21 January 2018

1 reference

A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity

21 January 2018

1 reference

Rethinking ALS: the FUS about TDP-43.

21 January 2018

1 reference

hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes

21 January 2018

1 reference

Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies

21 January 2018

1 reference

The many faces of α-synuclein: from structure and toxicity to therapeutic target

21 January 2018

1 reference

Animal models of Parkinson's disease: vertebrate genetics

21 January 2018

1 reference

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database

21 January 2018

1 reference

Rab GTPase regulation of retromer-mediated cargo export during endosome maturation

21 January 2018

1 reference

Protein disorder, prion propensities, and self-organizing macromolecular collectives.

21 January 2018

1 reference

Alpha-synuclein: from secretion to dysfunction and death

21 January 2018

1 reference

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

21 January 2018

1 reference

Aggregation of expanded polyglutamine domain in yeast leads to defects in endocytosis

21 January 2018

1 reference

Endocytosis machinery is involved in aggregation of proteins with expanded polyglutamine domains

21 January 2018

1 reference

Yeast as a model for studying human neurodegenerative disorders

21 January 2018

1 reference

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

Propagation of the prion phenomenon: beyond the seeding principle.

21 January 2018

1 reference

Molecular neuropathology of TDP-43 proteinopathies

21 January 2018

1 reference

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA.

21 January 2018

1 reference

Amyloid precursor protein processing and Alzheimer's disease

21 January 2018

1 reference

Trinucleotide Repeat Disorders

21 January 2018

1 reference

Dissection and design of yeast prions

21 January 2018

1 reference

Yeast as a drug discovery platform in Huntington's and Parkinson's diseases

21 January 2018

1 reference

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization

21 January 2018

1 reference

Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism

21 January 2018

1 reference

Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome

21 January 2018

1 reference

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

21 January 2018

1 reference

Mitochondrial diseases and the role of the yeast models

21 January 2018

1 reference

A synergistic small-molecule combination directly eradicates diverse prion strain structures

21 January 2018

1 reference

Human ORFeome version 1.1: a platform for reverse proteomics

21 January 2018

1 reference

Towards a proteome-scale map of the human protein–protein interaction network

21 January 2018

1 reference

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy

21 January 2018

1 reference

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

New anti-prion drugs make yeast blush.

21 January 2018

1 reference

Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2

21 January 2018

1 reference

Conserved metabolic regulatory functions of sirtuins

21 January 2018

1 reference

Polyglutamine diseases: emerging concepts in pathogenesis and therapy

21 January 2018

1 reference

alpha-Synuclein budding yeast model: toxicity enhanced by impaired proteasome and oxidative stress

21 January 2018

1 reference

LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

1 reference

Emergence and natural selection of drug-resistant prions

21 January 2018

1 reference

A neuronal isoform of the aplysia CPEB has prion-like properties

21 January 2018

1 reference

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III.

21 January 2018

1 reference

Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae

21 January 2018

1 reference

Sir2 is induced by oxidative stress in a yeast model of Huntington disease and its activation reduces protein aggregation.

21 January 2018

1 reference

Unfolding the role of protein misfolding in neurodegenerative diseases

21 January 2018

1 reference

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

Tau pathophysiology in neurodegeneration: a tangled issue

21 January 2018

1 reference

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

21 January 2018

1 reference

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

21 January 2018

1 reference

A yeast prion, Mod5, promotes acquired drug resistance and cell survival under environmental stress

21 January 2018

1 reference

Simple is good: yeast models of neurodegeneration.

21 January 2018

1 reference

Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease

21 January 2018

1 reference

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

21 January 2018

1 reference

Antiprion drugs as chemical tools to uncover mechanisms of prion propagation

21 January 2018

1 reference

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

21 January 2018

1 reference

Pathological roles of α-synuclein in neurological disorders

21 January 2018

1 reference

Protein solubility and protein homeostasis: a generic view of protein misfolding disorders

21 January 2018

1 reference

Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.

21 January 2018

1 reference

Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs

21 January 2018

1 reference

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 January 2018

1 reference

Chaperone networks in protein disaggregation and prion propagation

21 January 2018

1 reference

alpha-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease

21 January 2018

1 reference

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

21 January 2018

1 reference

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

21 January 2018

1 reference

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson

21 January 2018

1 reference

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

21 January 2018

1 reference

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

21 January 2018

1 reference

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

21 January 2018

1 reference

Biochemical, Cell Biological, and Genetic Assays to Analyze Amyloid and Prion Aggregation in Yeast

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.12271

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23600759%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

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