Inhibition of α-helix-mediated protein-protein interactions using designed molecules (Q38082945)

28 August 2017

Inhibition of α-helix-mediated protein-protein interactions using designed molecules (English)

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protein-protein interaction

28 August 2017

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4

Andrew J Wilson

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author name string

Valeria Azzarito

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1

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28 August 2017

Kérya Long

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2

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28 August 2017

Natasha S Murphy

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3

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28 August 2017

1 March 2013

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5

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28 August 2017

161-173

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28 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nchem.1568

28 August 2017

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Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

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Phage display selection of miniprotein binders of the Estrogen Receptor

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

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Biologic drugs set to top 2012 sales

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Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold

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12 December 2020

Inhibition of protein-protein interactions using designed molecules

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12 December 2020

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

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Nucleation effects in peptide foldamers

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A decade of fragment-based drug design: strategic advances and lessons learned

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Structural mimicry of the α-helix in aqueous solution with an isoatomic α/β/γ-peptide backbone

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Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.

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12 December 2020

Contemporary strategies for the stabilization of peptides in the alpha-helical conformation

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12 December 2020

Potent inhibitors of LXXLL-based protein-protein interactions.

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12 December 2020

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

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Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

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12 December 2020

Paralog-selective ligands for bcl-2 proteins

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Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

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beta-Peptides: from structure to function

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12 December 2020

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

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Synthetic non-peptide mimetics of alpha-helices

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12 December 2020

Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction

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12 December 2020

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

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12 December 2020

Beta-peptides with improved affinity for hDM2 and hDMX.

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12 December 2020

Design and structure of stapled peptides binding to estrogen receptors

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12 December 2020

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

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12 December 2020

N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.

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12 December 2020

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

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12 December 2020

Inhibition of HIV type 1 infectivity by constrained alpha-helical peptides: implications for the viral fusion mechanism

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12 December 2020

Molecular Recognition of Protein Surfaces: High Affinity Ligands for the CBP KIX Domain

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12 December 2020

Conformation of poly-.beta.-alanine in aqueous solution from proton magnetic resonance and deuterium exchange studies

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12 December 2020

Foldamers: A Manifesto

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Crossref

https://api.crossref.org/works/10.1038%2FNCHEM.1568

7 January 2021

inferred from DOI database lookup

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEM.1568

7 January 2021

inferred from DOI database lookup

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEM.1568

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEM.1568

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Dimensions Publication ID

28 August 2017

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