Coupling of receptor conformation and ligand orientation determine graded activity (Q27664921)

9

0 references

Pavel V Afonine

8

object named as

Pavel V Afonine

0 references

author name string

John B Bruning

1

0 references

Alexander A Parent

2

0 references

Min Zhao

4

0 references

Jason Nowak

5

0 references

Margaret C Pace

6

0 references

Carolyn L Smith

7

0 references

John A Katzenellenbogen

10

0 references

Kendall W Nettles

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes

11

0 references

publication date

November 2010

0 references

published in

Nature Chemical Biology

0 references

volume

6

0 references

issue

11

0 references

page(s)

837-43

0 references

cites work

1 reference

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NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

20 March 2017

1 reference

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Partial agonists activate PPARgamma using a helix 12 independent mechanism

20 March 2017

1 reference

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Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands

20 March 2017

1 reference

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Structural plasticity in the oestrogen receptor ligand-binding domain

20 March 2017

1 reference

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c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty

20 March 2017

1 reference

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Structural analysis of autoinhibition in the Ras activator Son of sevenless

20 March 2017

1 reference

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Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

20 March 2017

1 reference

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Structural basis for the autoinhibition of c-Abl tyrosine kinase

20 March 2017

1 reference

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

20 March 2017

1 reference

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Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

20 March 2017

1 reference

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The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12

20 March 2017

1 reference

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

20 March 2017

1 reference

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

20 March 2017

1 reference

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Structure and specificity of nuclear receptor-coactivator interactions

20 March 2017

1 reference

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Molecular basis of agonism and antagonism in the oestrogen receptor

20 March 2017

1 reference

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Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

20 March 2017

1 reference

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Coot: model-building tools for molecular graphics

20 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

20 March 2017

1 reference

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

PHENIX: building new software for automated crystallographic structure determination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Intrinsic dynamics of an enzyme underlies catalysis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

The CCP4 molecular-graphics project

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Allosteric modulation of kinases and GPCRs: design principles and structural diversity

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Molecular basis of selective PPARgamma modulation for the treatment of Type 2 diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Benzopyrans are selective estrogen receptor beta agonists with novel activity in models of benign prostatic hyperplasia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Dynamically driven protein allostery.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Visualizing polynucleotide polymerase machines at work

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

An NMR perspective on enzyme dynamics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

A natural product ligand of the oxysterol receptor, liver X receptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

The linkage between protein folding and functional cooperativity: two sides of the same coin?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Nucleotide switches in molecular motors: structural analysis of kinesins and myosins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Theory of protein folding: the energy landscape perspective

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Ligand binding and internal equilibiums in proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.

19 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974172

Two-state allosteric behavior in a single-domain signaling protein

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20924370

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.451

1 reference

Dimensions Publication ID

2140758

1021902154

0 references

2140758

1 reference

1 reference

1 reference