Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target (Q38071660)

28 August 2017

1 reference

title

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target (English)

1 reference

28 August 2017

Sabine André

2

1 reference

ORCID Public Data File 2021

author name string

Karel Smetana

1

1 reference

28 August 2017

Herbert Kaltner

3

1 reference

28 August 2017

Jürgen Kopitz

4

1 reference

28 August 2017

Hans-Joachim Gabius

5

1 reference

28 August 2017

language of work or name

English

0 references

publication date

6 January 2013

1 reference

Expert Opinion on Therapeutic Targets

28 August 2017

1 reference

28 August 2017

17

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28 August 2017

4

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28 August 2017

379-392

1 reference

From lectin structure to functional glycomics: principles of the sugar code.

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Lectins for histochemical demonstration of glycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

A beta-D-galactoside binding protein from electric organ tissue of Electrophorus electricus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectins: a family of animal lectins that decipher glycocodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectinomics: finding themes in complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Unique chicken tandem-repeat-type galectin: implications of alternative splicing and a distinct expression profile compared to those of the three proto-type proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Glycosylation, galectins and cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

How does it act when soluble? Critical evaluation of mechanism of galectin-1 induced T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectins in acute and chronic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

The sequence of the mouse 14 kDa beta-galactoside-binding lectin and evidence for its synthesis on free cytoplasmic ribosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Nuclear presence of adhesion-/growth-regulatory galectins in normal/malignant cells of squamous epithelial origin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

SR proteins and galectins: what's in a name?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Isolation of a cDNA clone, encoding a human β-galactoside binding protein, overexpressed during glucocorticoid-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Modulation of galactoside-binding lectins in tumor cells by differentiation-inducing agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Effect of 5-azacytidine and galectin-1 on growth and differentiation of the human b lymphoma cell line bl36

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Oxidation and chemical modification of lung beta-galactoside-specific lectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: different structural alterations upon oxidation and ligand binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Identification of an autocrine negative growth factor: mouse beta-galactoside-binding protein is a cytostatic factor and cell growth regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Overexpression of a beta-galactoside binding protein causes transformation of BALB3T3 fibroblast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Structural and functional studies of galectin-1: a novel axonal regeneration-promoting activity for oxidized galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Homodimeric chicken galectin CG-1B (C-14): Crystal structure and detection of unique redox-dependent shape changes involving inter- and intrasubunit disulfide bridges by gel filtration, ultracentrifugation, site-directed mutagenesis, and [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Receptor for the cell binding site of discoidin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Multifunctional proteins: examples of gene sharing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Moonlighting is mainstream: paradigm adjustment required

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor α5β1-integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Ganglioside GM1 deficiency in effector T cells from NOD mice induces resistance to regulatory T-cell suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Identification of galectin-1 as a critical factor in function of mouse mesenchymal stromal cell-mediated tumor promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Biphasic modulation of cell growth by recombinant human galectin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1: a bifunctional regulator of cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Suppression of autoimmune diabetes by soluble galectin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1-induced down-regulation of T lymphocyte activation protects (NZB x NZW) F1 mice from lupus-like disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Toward bioinspired galectin mimetics: identification of ligand-contacting peptides by proteolytic-excision mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Negative regulation of neuroblastoma cell growth by carbohydrate-dependent surface binding of galectin-1 and functional divergence from galectin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Combining carbohydrate substitutions at bioinspired positions with multivalent presentation towards optimising lectin inhibitors: case study with calixarenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Compensation of loss of protein function in microsatellite-unstable colon cancer cells (HCT116): a gene-dependent effect on the cell surface glycan profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Human galectin-3 (Mac-2 antigen): defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Glycosylation of mouse and human immune cells: insights emerging from N-glycomics analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Lgals6, a 2-million-year-old gene in mice: a case of positive Darwinian selection and presence/absence polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Human deficiencies of fucosylation and sialylation affecting selectin ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Two opposing roles of O-glycans in tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Drug development: Raise standards for preclinical cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Assumptions of expected benefits in randomized phase III trials evaluating systemic treatments for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Toward automated glycan analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Mannan-binding lectin deficiency - Good news, bad news, doesn't matter?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: Increased expression of galectin-1 and induction of poor prognosis factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Galectin-3 – an emerging prognostic indicator in advanced head and neck carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.750651

10.1517/14728222.2013.750651

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference