Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2 (Q30519464)

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4 February 2020

title

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2 (English)

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4 February 2020

7

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4 February 2020

author name string

Dávid Héja

1

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4 February 2020

Andrea Kocsis

2

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4 February 2020

József Dobó

3

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4 February 2020

Katalin Szilágyi

4

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4 February 2020

Róbert Szász

5

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4 February 2020

Péter Závodszky

6

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4 February 2020

Péter Gál

8

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4 February 2020

language of work or name

English

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publication date

12 June 2012

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Proceedings of the National Academy of Sciences of the United States of America

4 February 2020

published in

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4 February 2020

volume

109

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4 February 2020

issue

26

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4 February 2020

page(s)

10498-10503

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Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2

4 February 2020

cites work

1 reference

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Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.

20 June 2018

1 reference

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The role of ficolins in the lectin pathway of innate immunity

20 June 2018

1 reference

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Functional analysis of Ficolin-3 mediated complement activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity

20 June 2018

1 reference

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Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation

20 June 2018

1 reference

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Ficolins: complement-activating lectins involved in innate immunity

20 June 2018

1 reference

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Pattern recognition receptors and inflammation

20 June 2018

1 reference

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A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation

20 June 2018

1 reference

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Sodium polyanethole sulfonate as an inhibitor of activation of complement function in blood culture systems

20 June 2018

1 reference

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MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Complement-targeted therapeutics

20 June 2018

1 reference

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Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Mannose-binding lectin in innate immunity: past, present and future

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Identification of the target self-antigens in reperfusion injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3387078

Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene.

20 June 2018

1 reference

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Serum lectin with known structure activates complement through the classical pathway.

20 June 2018

1 reference

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Mannan-binding lectin (MBL)-associated serine protease-1 (MASP-1), a serine protease associated with humoral pattern-recognition molecules: normal and acute-phase levels in serum and stoichiometry of lectin pathway components

20 June 2018

1 reference

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A true autoactivating enzyme. Structural insight into mannose-binding lectin-associated serine protease-2 activations

26 November 2018

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Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA.

26 November 2018

1 reference

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An assay for the mannan-binding lectin pathway of complement activation

26 November 2018

1 reference

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Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury

26 November 2018

1 reference

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Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22691502

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1202588109

1 reference

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4 February 2020

0 references

1 reference

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4 February 2020

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