Minimizing the damage: repair pathways keep mitochondrial DNA intact (Q38044810)

27 August 2017

Minimizing the damage: repair pathways keep mitochondrial DNA intact (English)

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27 August 2017

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3

Ian J Holt

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27 August 2017

Lawrence Kazak

1

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PubMed ID

22992591

27 August 2017

Aurelio Reyes

series ordinal

2

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27 August 2017

20 September 2012

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Nature Reviews Molecular Cell Biology

27 August 2017

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27 August 2017

13

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27 August 2017

10

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27 August 2017

659-671

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https://scigraph.springernature.com/pub.10.1038/nrm3439

27 August 2017

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In situ analysis of repair processes for oxidative DNA damage in mammalian cells.

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Long patch base excision repair in mammalian mitochondrial genomes

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Efficient repair of abasic sites in DNA by mitochondrial enzymes

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Mammalian base excision repair by DNA polymerases delta and epsilon

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Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

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UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles

31 March 2020

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Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction

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Membrane association of mitochondrial DNA facilitates base excision repair in mammalian mitochondria

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The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.

31 March 2020

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Direct visualization of a DNA glycosylase searching for damage

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A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

31 March 2020

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5,6-Saturated thymine lesions in DNA: production by ultraviolet light or hydrogen peroxide

31 March 2020

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X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine

31 March 2020

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Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA

31 March 2020

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Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene

31 March 2020

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Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

31 March 2020

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Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage

31 March 2020

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Molecular and biological roles of Ape1 protein in mammalian base excision repair

31 March 2020

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Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals

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Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes

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The DNA replication fork in eukaryotic cells.

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Oxidative DNA damage repair in mammalian cells: a new perspective

31 March 2020

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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

31 March 2020

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Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2

31 March 2020

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NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells

31 March 2020

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AP endonuclease-independent DNA base excision repair in human cells

31 March 2020

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Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome

31 March 2020

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Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair

31 March 2020

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The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells

31 March 2020

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Identification of a beta-like DNA polymerase activity in bovine heart mitochondria.

31 March 2020

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Identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro

31 March 2020

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The influence of the DNA polymerase gamma accessory subunit on base excision repair by the catalytic subunit

31 March 2020

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ATP-dependent DNA ligases

31 March 2020

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Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria

31 March 2020

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Alternative nucleotide incision repair pathway for oxidative DNA damage

31 March 2020

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Characterization of a catalytically slow AP lyase activity in DNA polymerase gamma and other family A DNA polymerases

31 March 2020

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Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication

31 March 2020

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Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae

31 March 2020

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RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

31 March 2020

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Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

31 March 2020

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Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

31 March 2020

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Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity

31 March 2020

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A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

31 March 2020

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Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

31 March 2020

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Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair

31 March 2020

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Mitochondrial DNA ligase III function is independent of Xrcc1.

31 March 2020

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Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma

31 March 2020

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p53 Protein exhibits 3'-to-5' exonuclease activity

31 March 2020

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p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria

31 March 2020

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The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells.

31 March 2020

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RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress.

31 March 2020

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Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging

31 March 2020

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The mitochondrial transcription factor A functions in mitochondrial base excision repair

31 March 2020

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HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease

31 March 2020

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Role of high mobility group (HMG) chromatin proteins in DNA repair.

31 March 2020

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Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

31 March 2020

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Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites

31 March 2020

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Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA

31 March 2020

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mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored

31 March 2020

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The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

31 March 2020

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Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1

31 March 2020

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Mitochondrial DNA replication and repair: all a flap

31 March 2020

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Single-strand break repair and genetic disease

31 March 2020

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Repair of persistent strand breaks in the mitochondrial genome

31 March 2020

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Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity

31 March 2020

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Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

31 March 2020

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PARP is important for genomic stability but dispensable in apoptosis

31 March 2020

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A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence.

31 March 2020

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ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).

31 March 2020

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Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria

31 March 2020

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The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

31 March 2020

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Aprataxin localizes to mitochondria and preserves mitochondrial function

31 March 2020

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The MRE11 complex: starting from the ends.

31 March 2020

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Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

31 March 2020

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Double-strand break end resection and repair pathway choice

31 March 2020

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Mre11 is expressed in mammalian mitochondria where it binds to mitochondrial DNA.

31 March 2020

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Mitochondrial genome maintenance: roles for nuclear nonhomologous end-joining proteins in Saccharomyces cerevisiae

31 March 2020

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Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.

31 March 2020

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Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome

31 March 2020

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TEFM (c17orf42) is necessary for transcription of human mtDNA

31 March 2020

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Mammalian mitochondria possess homologous DNA recombination activity

31 March 2020

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Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background

31 March 2020

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Heterologous mitochondrial DNA recombination in human cells

31 March 2020

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Mitochondrial nucleoids maintain genetic autonomy but allow for functional complementation

31 March 2020

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Activation of XerCD-dif recombination by the FtsK DNA translocase

31 March 2020

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The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA

31 March 2020

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Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication

31 March 2020

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Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA.

31 March 2020

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Sequence and organization of the human mitochondrial genome

31 March 2020

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Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA.

31 March 2020

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Mechanisms in eukaryotic mismatch repair

31 March 2020

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Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome.

31 March 2020

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Mismatch repair activity in mammalian mitochondria

31 March 2020

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Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

31 March 2020

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Global analysis of protein expression in yeast

31 March 2020

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Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.

31 March 2020

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Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells

31 March 2020

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Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress

31 March 2020

1 reference

A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair

31 March 2020

1 reference

Mechanisms and functions of DNA mismatch repair

31 March 2020

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Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in Yeast

31 March 2020

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Endonucleolytic function of MutLalpha in human mismatch repair.

31 March 2020

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YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repair proteins

31 March 2020

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Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs

31 March 2020

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Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells

31 March 2020

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Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen

31 March 2020

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31 March 2020

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DNA damage tolerance, mismatch repair and genome instability

31 March 2020

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DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response.

31 March 2020

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Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells

31 March 2020

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Oxidative stress induces degradation of mitochondrial DNA

31 March 2020

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Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers

31 March 2020

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Action of mitochondrial endonuclease G on DNA damaged by L-ascorbic acid, peplomycin, and cis-diamminedichloroplatinum (II)

31 March 2020

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31 March 2020

Mechanisms of mitophagy

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DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair

31 March 2020

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Importing mitochondrial proteins: machineries and mechanisms

31 March 2020

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Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells

31 March 2020

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Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA.

31 March 2020

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The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus

31 March 2020

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Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.

31 March 2020

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The 5' region of the human hSUV3 gene encoding mitochondrial DNA and RNA helicase: promoter characterization and alternative pre-mRNA splicing.

31 March 2020

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Mitochondrial and nuclear localization of human Pif1 helicase.

31 March 2020

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Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat

31 March 2020

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Determinants and dynamics of genome accessibility

31 March 2020

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Initial impact of the sequencing of the human genome

31 March 2020

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Mammalian mitochondrial nucleoids: organizing an independently minded genome.

31 March 2020

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The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria

31 March 2020

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Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.

31 March 2020

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31 March 2020

RNA-templated DNA repair

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Reconstitution of a minimal mtDNA replisome in vitro

31 March 2020

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Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication

31 March 2020

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Bidirectional replication initiates at sites throughout the mitochondrial genome of birds

31 March 2020

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The mitochondrial theory of aging: dead or alive?

31 March 2020

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Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

31 March 2020

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Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.

31 March 2020

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Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria.

31 March 2020

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Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

31 March 2020

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Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin

31 March 2020

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TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

31 March 2020

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The MFN2 gene is responsible for mitochondrial DNA instability and optic atrophy 'plus' phenotype.

31 March 2020

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Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

31 March 2020

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What causes mitochondrial DNA deletions in human cells?

31 March 2020

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Artificial restriction DNA cutters to promote homologous recombination in human cells

31 March 2020

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Minimum length of sequence homology required for in vivo cloning by homologous recombination in yeast

31 March 2020

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The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA.

31 March 2020

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Mitochondrial DNA: does more lead to less?

31 March 2020

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Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age.

31 March 2020

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Resistance of HeLa cell mitochondrial DNA to mutagenesis by chemical carcinogens.

31 March 2020

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12 December 2020

Genetic analyses of Schizosaccharomyces pombe dna2(+) reveal that dna2 plays an essential role in Okazaki fragment metabolism

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12 December 2020

Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice

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12 December 2020

Characterization of the effects of a thymine glycol residue on the structure, dynamics, and stability of duplex DNA by NMR

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12 December 2020

Identification and characterization of yeast mutants and the gene for a cruciform cutting endonuclease

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12 December 2020

Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response.

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12 December 2020

Identifiers

DOI

10.1038/NRM3439

1 reference

PubMed ID

22992591

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22992591