Systems biology for molecular life sciences and its impact in biomedicine (Q38035735)

27 August 2017

Systems biology for molecular life sciences and its impact in biomedicine (English)

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27 August 2017

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1

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27 August 2017

19 August 2012

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Cellular and Molecular Life Sciences

27 August 2017

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27 August 2017

70

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27 August 2017

1035-1053

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27 August 2017

6

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https://scigraph.springernature.com/pub.10.1007/s00018-012-1109-z

27 August 2017

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Mapping the human protein interactome.

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21 January 2018

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Integrating interactome, phenome, and transcriptome mapping data for the C. elegans germline

21 January 2018

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A human phenome-interactome network of protein complexes implicated in genetic disorders

21 January 2018

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Multi-level reproducibility of signature hubs in human interactome for breast cancer metastasis

21 January 2018

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Expanding the mitochondrial interactome.

21 January 2018

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MitoInteractome: mitochondrial protein interactome database, and its application in 'aging network' analysis

21 January 2018

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A human MAP kinase interactome

21 January 2018

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The urokinase receptor interactome

21 January 2018

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Charting the NF-κB pathway interactome map

21 January 2018

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An in vivo map of the yeast protein interactome

21 January 2018

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Making connections for life: an in vivo map of the yeast interactome

21 January 2018

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Toward the dynamic interactome: it's about time

21 January 2018

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A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae

21 January 2018

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Walking the interactome for prioritization of candidate disease genes

21 January 2018

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Mapping the disease protein interactome: toward a molecular medicine GPS to accelerate drug and biomarker discovery

21 January 2018

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Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease

21 January 2018

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Interactome networks and human disease

21 January 2018

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Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses

21 January 2018

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APID2NET: unified interactome graphic analyzer.

21 January 2018

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Integration of biological networks and gene expression data using Cytoscape

21 January 2018

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Cytoscape 2.8: new features for data integration and network visualization

21 January 2018

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Exploring and challenging the network of angiogenesis.

21 January 2018

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On a fundamental structure of gene networks in living cells

21 January 2018

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Systems biology: the elements and principles of life

21 January 2018

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Mathematical modeling of polyamine metabolism in mammals.

21 January 2018

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BioModels.net Web Services, a free and integrated toolkit for computational modelling software

21 January 2018

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Biochemical systems analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions.

21 January 2018

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KEGG: kyoto encyclopedia of genes and genomes

21 January 2018

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Computational modeling of biochemical networks using COPASI

21 January 2018

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Systems biology metabolic modeling assistant: an ontology-based tool for the integration of metabolic data in kinetic modeling.

21 January 2018

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BioMet Toolbox: genome-wide analysis of metabolism

21 January 2018

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Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0

21 January 2018

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Biochemical systems analysis of genome-wide expression data

21 January 2018

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Global reconstruction of the human metabolic network based on genomic and bibliomic data

21 January 2018

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Genome-scale metabolic networks

21 January 2018

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Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions

21 January 2018

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21 January 2018

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Flux balance analysis in the era of metabolomics

21 January 2018

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Flux balance analysis of biological systems: applications and challenges.

21 January 2018

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Capturing the essence of a metabolic network: a flux balance analysis approach.

21 January 2018

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What is flux balance analysis?

21 January 2018

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The application of flux balance analysis in systems biology

21 January 2018

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Two-stage flux balance analysis of metabolic networks for drug target identification

21 January 2018

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A framework for mapping, visualisation and automatic model creation of signal-transduction networks

21 January 2018

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Systems chemical biology and the Semantic Web: what they mean for the future of drug discovery research

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Techniques: application of systems biology to absorption, distribution, metabolism, excretion and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Anti-angiogenic drugs: from bench to clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Do not say ever never more: the ins and outs of antiangiogenic therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Playing only one instrument may be not enough: limitations and future of the antiangiogenic treatment of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Synergistic drug combinations tend to improve therapeutically relevant selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systematic exploration of synergistic drug pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Network pharmacology: the next paradigm in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Network analyses in systems pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems pharmacology of complex diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems pharmacology: network analysis to identify multiscale mechanisms of drug action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

In silico models of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Predictive modeling in cancer: where systems biology meets the stock market.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

In silico cancer modeling: is it ready for prime time?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

An ordinary differential equation model for the multistep transformation to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Mathematical modeling of ovarian cancer treatments: sequencing of surgery and chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Modeling the effect of tumor size in early breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Multiparameter computational modeling of tumor invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Mathematical modelling of dynamic adaptive tumour-induced angiogenesis: clinical implications and therapeutic targeting strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A cell-based model exhibiting branching and anastomosis during tumor-induced angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems biology for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Cancer: a Systems Biology disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems biology and cancer: promises and perils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Fractal analysis in a systems biology approach to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems biology: confronting the complexity of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems biology and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A systems biology approach to defining metastatic biomarkers and signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systematic identification of genomic markers of drug sensitivity in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Cancer systems biology: exploring cancer-associated genes on cellular networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Cancer systems biology: a network modeling perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A systems biology approach reveals common metastatic pathways in osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Google goes cancer: improving outcome prediction for cancer patients by network-based ranking of marker genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Disrupting the networks of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Mining gene expression profiles: expression signatures as cancer phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

The consensus coding sequences of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A five-gene signature and clinical outcome in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A network medicine approach to human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Network medicine in drug design: implications for neuroinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Systems biology and the future of medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

The human disease network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

The implications of human metabolic network topology for disease comorbidity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A dynamic network approach for the study of human phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

The orphan disease networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A whole-cell computational model predicts phenotype from genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

The dawn of virtual cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

A network-based approach to quantifying the impact of biologically active substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

Network Medicine Strikes a Blow against Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1109-Z

The Edinburgh human metabolic network reconstruction and its functional analysis

21 January 2018

1 reference

12 December 2020

Biochemical systems analysis. 3. Dynamic solutions using a power-law approximation

1 reference

12 December 2020

A combined model of hepatic polyamine and sulfur amino acid metabolism to analyze S-adenosyl methionine availability

1 reference

12 December 2020

Systems biology and cancer prevention: all options on the table

1 reference

12 December 2020

Consilience, complexity, and communication: three challenges at the start of the new century

1 reference

12 December 2020

A stochastic model of cancer initiation including a bystander effect

1 reference

12 December 2020

Network medicine--from obesity to the "diseasome"

1 reference

12 December 2020

Interactome: gateway into systems biology

1 reference

12 December 2020

Synergy research: approaching a new generation of phytopharmaceuticals

1 reference

12 December 2020

A map of human cancer signaling

1 reference

12 December 2020

Identification of high-quality cancer prognostic markers and metastasis network modules

1 reference

12 December 2020

A systems biology view of cancer

1 reference

12 December 2020

Biochemical systems analysis. II. The steady-state solutions for an n-pool system using a power-law approximation

1 reference

12 December 2020

10.1007/S00018-012-1109-Z

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22903296