A network medicine approach to human disease (Q37408792)

20 August 2017

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title

A network medicine approach to human disease (English)

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20 August 2017

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3

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20 August 2017

Andreas Zanzoni

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author name string

Montserrat Soler-López

series ordinal

2

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PubMed ID

19269289

20 August 2017

language of work or name

English

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publication date

6 March 2009

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20 August 2017

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20 August 2017

583

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20 August 2017

1759-1765

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20 August 2017

11

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Initial sequencing and analysis of the human genome

20 August 2017

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

The Sequence of the Human Genome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A novel genetic system to detect protein-protein interactions

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A generic protein purification method for protein complex characterization and proteome exploration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split-ubiquitin membrane yeast two-hybrid analysis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A comprehensive two-hybrid analysis to explore the yeast protein interactome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Proteome survey reveals modularity of the yeast cell machinery

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A protein interaction map of Drosophila melanogaster

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A map of the interactome network of the metazoan C. elegans

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Towards a proteome-scale map of the human protein–protein interaction network

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

High-quality binary protein interaction map of the yeast interactome network

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

An empirical framework for binary interactome mapping

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Monogenic traits are not simple: lessons from phenylketonuria

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Modifier genes convert "simple" Mendelian disorders to complex traits

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Beyond Mendel: an evolving view of human genetic disease transmission

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

The modular nature of genetic diseases.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Protein interactions in human genetic diseases.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

The von Hippel-Lindau tumor suppressor protein

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

MINT: the Molecular INTeraction database

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

IntAct--open source resource for molecular interaction data

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

The human disease network

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Network properties of genes harboring inherited disease mutations

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Discovering disease-genes by topological features in human protein-protein interaction network.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Low duplicability and network fragility of cancer genes

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Effects of HER2 overexpression on cell signaling networks governing proliferation and migration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Quantitative monitoring of gene expression patterns with a complementary DNA microarray

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Gene expression patterns in human liver cancers

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Gene expression profiling predicts clinical outcome of breast cancer

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A network-based analysis of systemic inflammation in humans

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Protein networks in disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A human protein-protein interaction network: a resource for annotating the proteome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Network-based classification of breast cancer metastasis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Large-scale mapping of human protein-protein interactions by mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Network modeling links breast cancer susceptibility and centrosome dysfunction

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Targeting and tinkering with interaction networks

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Towards a molecular characterisation of pathological pathways.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

21 January 2018

Biological robustness

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Peptides mediating interaction networks: new leads at last

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Small-molecule inhibition of TNF-alpha

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Approved drug mimics of short peptide ligands from protein interaction motifs

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

The genetic basis of variability in drug responses

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Accurate whole human genome sequencing using reversible terminator chemistry

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

The diploid genome sequence of an Asian individual

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Network pharmacology: the next paradigm in drug discovery

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

How many drug targets are there?

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

What does systems biology mean for drug development?

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

The coxibs, selective inhibitors of cyclooxygenase-2.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Coxibs and heart disease: what we have learned and what else we need to know

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Global mapping of pharmacological space

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A ligand-based approach to mining the chemogenomic space of drugs

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A global view of drug-therapy interactions

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Memoquin: a multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Targeting QseC signaling and virulence for antibiotic development

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Design and application of diabodies, triabodies and tetrabodies for cancer targeting

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

A robustness-based approach to systems-oriented drug design.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Finding new tricks for old drugs: an efficient route for public-sector drug discovery

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Drug target identification using side-effect similarity

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Drug repositioning: identifying and developing new uses for existing drugs

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Clinical pharmacology in the era of biotherapeutics.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Protein therapeutics: a summary and pharmacological classification

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Hedgehog signaling and congenital malformations

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.03.001

10.1016/J.FEBSLET.2009.03.001

21 January 2018

Identifiers

DOI

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20 August 2017

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PubMed ID

19269289