G-quadruplexes: targets and tools in anticancer drug design (Q37994254)

26 August 2017

G-quadruplexes: targets and tools in anticancer drug design (English)

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26 August 2017

1

Markus Düchler

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26 August 2017

19 March 2012

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Journal of Drug Targeting

26 August 2017

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26 August 2017

20

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26 August 2017

5

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26 August 2017

389-400

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Selective targeting of G-quadruplex using furan-based cyclic homooligopeptides: effect on c-MYC expression

26 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Repression of translation of human estrogen receptor alpha by G-quadruplex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Making sense of G-quadruplex and i-motif functions in oncogene promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex

21 January 2018

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https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Quadruplex DNA: sequence, topology and structure

21 January 2018

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https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Structural basis of telomeric RNA quadruplex--acridine ligand recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Quadruplex ligands may act as molecular chaperones for tetramolecular quadruplex formation

21 January 2018

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https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Shelterin: the protein complex that shapes and safeguards human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription

21 January 2018

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https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Promoting transcription of chromosome ends.

21 January 2018

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https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

TERRA biogenesis, turnover and implications for function.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Nucleic acid aptamers based on the G-quadruplex structure: therapeutic and diagnostic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Mutations in the G-quadruplex silencer element and their relationship to c-MYC overexpression, NM23 repression, and therapeutic rescue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescence

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-rich oligonucleotides inhibit HIF-1alpha and HIF-2alpha and block tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Targeting pancreatic cancer with a G-quadruplex ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

HIV-1 inactivation by nucleic acid aptamers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1

21 January 2018

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https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-quadruplexes in promoters throughout the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Research progress of RNA quadruplex

21 January 2018

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https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Position and stability are determining factors for translation repression by an RNA G-quadruplex-forming sequence within the 5' UTR of the NRAS proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Structure of the Human Telomere in K + Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Coexistence of two distinct G-quadruplex conformations in the hTERT promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-quadruplex structures: in vivo evidence and function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Triethylene tetramine, a novel ligand of G-quadruplex, induces senescence of MCF-7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-quadruplex-induced instability during leading-strand replication

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Telomerase structure function.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Telomere targeting with a new G4 ligand enhances radiation-induced killing of human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Water soluble cationic perylene derivatives as possible telomerase inhibitors: the search for selective G-quadruplex targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

An unusually stable G-quadruplex within the 5'-UTR of the MT3 matrix metalloproteinase mRNA represses translation in eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The structures of quadruplex nucleic acids and their drug complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Human telomeric G-quadruplex: structures of DNA and RNA sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Exon array analyses across the NCI-60 reveal potential regulation of TOP1 by transcription pausing at guanosine quartets in the first intron

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-rich oligonucleotides alter cell cycle progression and induce apoptosis specifically in OE19 esophageal tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The BCL-2 5' untranslated region contains an RNA G-quadruplex-forming motif that modulates protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Telomere maintenance as therapeutic target in embryonal tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Inducement of G-quadruplex DNA forming and down-regulation of oncogene c-myc by bile acid-amino acid conjugate-BAA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Structure-based design of platinum(II) complexes as c-myc oncogene down-regulators and luminescent probes for G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

G-quadruplex nucleic acids and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Telomeric repeat-containing RNA structure in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Novel modular DNA aptamer for human thrombin with high anticoagulant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

BNIP-Salpha induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2012.669384

10.3109/1061186X.2012.669384

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22424091