The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents. (Q34011118)

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English	The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.	scientific article

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5 January 2020

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents (English)

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5 January 2020

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author name string

Daekyu Sun

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5 January 2020

Kexiao Guo

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5 January 2020

Jadrian J Rusche

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5 January 2020

Scot Ebbinghaus

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Vijay Gokhale

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Laurence H Hurley

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publication date

1 April 2008

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5 January 2020

Molecular Cancer Therapeutics

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4

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5 January 2020

880-889

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5 January 2020

Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of PDGF-A promoter activity by TMPyP4

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Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene

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Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.

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Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives

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5 July 2018

G-quadruplexes in promoters throughout the human genome

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NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region

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G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

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Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter

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Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter

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Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents

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Transcriptional regulation of vascular endothelial growth factor in cancer.

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5 July 2018

Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter

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A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

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5 July 2018

New molecular pathways in angiogenesis

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Tumor angiogenesis and accessibility: role of vascular endothelial growth factor

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5 July 2018

Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements

1 reference

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5 July 2018

Recent advances in angiogenesis, anti-angiogenesis and vascular targeting

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5 July 2018

Antiangiogenic agents targeting vascular endothelial growth factor and its receptors in clinical development

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5 July 2018

Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription

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VEGF-Trap: a VEGF blocker with potent antitumor effects

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5 July 2018

CD of single-stranded, double-stranded, and G-quartet nucleic acids in complexes with a single-stranded DNA-binding protein

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5 July 2018

Crystal structure of parallel quadruplexes from human telomeric DNA

1 reference

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5 July 2018

Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors

1 reference

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Effect of VEGF receptor inhibitor PTK787/ZK222584 [correction of ZK222548] combined with ionizing radiation on endothelial cells and tumour growth

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Role of protein kinase Czeta in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression

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5 July 2018

A DNA polymerase stop assay for G-quadruplex-interactive compounds

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5 July 2018

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

1 reference

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5 July 2018

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5 July 2018

Tumor angiogenesis: therapeutic implications

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29 October 2018

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1 reference

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29 October 2018

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1 reference

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29 October 2018

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29 October 2018

The molecular perspective: VEGF and angiogenesis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

1 reference

https://pubmed.ncbi.nlm.nih.gov/18413801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective interactions of cationic porphyrins with G-quadruplex structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18413801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18413801

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-07-2119

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18413801%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18413801%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18413801%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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