Ewing sarcoma: biology-based therapeutic perspectives (Q37981253)

26 August 2017

title

Ewing sarcoma: biology-based therapeutic perspectives (English)

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26 August 2017

Jenny Potratz

1

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26 August 2017

Heribert Jürgens

series ordinal

2

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26 August 2017

Alan Craft

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3

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26 August 2017

Uta Dirksen

series ordinal

4

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26 August 2017

publication date

1 February 2012

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Pediatric Hematology and Oncology

26 August 2017

published in

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26 August 2017

volume

29

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26 August 2017

issue

1

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26 August 2017

page(s)

12-27

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Mechanisms of sarcoma development

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

EWS-ETS oncoproteins: the linchpins of Ewing tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Microsatellites as EWS/FLI response elements in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

The Biology of Ewing sarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Ethnic and racial differences in patients with Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Interethnic polymorphism of EWS intron 6: genome plasticity mediated by Alu retroposition and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Response of Ewing tumor cells to forced and activated p53 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Mesenchymal stem cell features of Ewing tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Polycomb silencers control cell fate, development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

The discovery of receptor tyrosine kinases: targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Biological rationale and current clinical experience with anti-insulin-like growth factor 1 receptor monoclonal antibodies in treating sarcoma: twenty years from the bench to the bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Targeting IGF-1R: throwing out the baby with the bathwater?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

C-kit receptor expression in Ewing's sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Phase II multicenter trial of imatinib in 10 histologic subtypes of sarcoma using a bayesian hierarchical statistical model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Defining the role of mTOR in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Phase I study of everolimus in pediatric patients with refractory solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Reduced human leukocyte antigen expression in advanced-stage Ewing sarcoma: implications for immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

A high proportion of bone marrow T cells with regulatory phenotype (CD4+CD25hiFoxP3+) in Ewing sarcoma patients is associated with metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Pilot trial of tumor-specific peptide vaccination and continuous infusion interleukin-2 in patients with recurrent Ewing sarcoma and alveolar rhabdomyosarcoma: an inter-institute NIH study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

A pilot study of consolidative immunotherapy in patients with high-risk pediatric sarcomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Targeting CD99 in association with doxorubicin: an effective combined treatment for Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Tumor metastasis: mechanistic insights and clinical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Cell adhesion and signalling by cadherins and Ig-CAMs in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Late recurrence in pediatric cancer: a report from the Childhood Cancer Survivor Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Stem cells, cancer, and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Tumour stem cells and drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Identification of side population cells (stem-like cell population) in pediatric solid tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Gli and hedgehog in cancer: tumours, embryos and stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

A phase I clinical trial of darinaparsin in patients with refractory solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

The Ewing Family of Tumors -- A Subgroup of Small-Round-Cell Tumors Defined by Specific Chimeric Transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08880018.2011.627582

10.3109/08880018.2011.627582

21 January 2018

Identifiers

DOI

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26 August 2017

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