The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts (Q38287718)

1 September 2017

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts (English)

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1 September 2017

3

Todd R Golub

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1 September 2017

Stephen L Lessnick

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PubMed ID

12086853

1 September 2017

Caroline S Dacwag

series ordinal

2

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1 September 2017

1 May 2002

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1 September 2017

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1 September 2017

1

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1 September 2017

4

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1 September 2017

393-401

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MIC2 is a specific marker for ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberrati

1 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

E1A signaling to p53 involves the p19(ARF) tumor suppressor

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Molecular genetics of chromosome translocations involving EWS and related family members

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Regulation of p53 stability by Mdm2

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

MDM2 and CDK4 gene amplification in Ewing's sarcoma.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

p19ARF links the tumour suppressor p53 to Ras

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Analysis of the p16INK4 and TP53 tumor suppressor genes in bone sarcoma pediatric patients

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Mechanisms of apoptosis by c-Myc

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Gene fusions encoding chimaeric transcription factors in solid tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Role of p14(ARF) in replicative and induced senescence of human fibroblasts

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900056-9

7 January 2021

10.1016/S1535-6108(02)00056-9

Identifiers

DOI

1 reference

1 September 2017

1 reference

PubMed ID

12086853