The role of autophagy in endoplasmic reticulum stress-induced pancreatic β cell death (Q37976952)

26 August 2017

The role of autophagy in endoplasmic reticulum stress-induced pancreatic β cell death (English)

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26 August 2017

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endoplasmic reticulum

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Jia-Jing Yin

1

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26 August 2017

Yan-Bo Li

2

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26 August 2017

Yang Wang

3

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26 August 2017

Guo-Dong Liu

4

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26 August 2017

Jun Wang

5

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26 August 2017

Xiao-Ou Zhu

6

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26 August 2017

Shang-Ha Pan

7

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26 August 2017

1 February 2012

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26 August 2017

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26 August 2017

8

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26 August 2017

2

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26 August 2017

158-164

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Autophagy in the Pathogenesis of Disease

26 August 2017

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Autophagy in human type 2 diabetes pancreatic beta cells.

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

ER-phagy: selective autophagy of the endoplasmic reticulum.

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The emerging role of autophagy in the pathophysiology of diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The double-edged effect of autophagy in pancreatic beta cells and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Autophagy as a cell death and tumor suppressor mechanism

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Cell death modalities: classification and pathophysiological implications

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Protective role of autophagy in palmitate-induced INS-1 beta-cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

β-cell autophagy: A novel mechanism regulating β-cell function and mass: Lessons from β-cell-specific Atg7-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Activation of autophagy through modulation of 5'-AMP-activated protein kinase protects pancreatic beta-cells from high glucose.

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The endoplasmic reticulum: a multifunctional signaling organelle

21 January 2018

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https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

From acute ER stress to physiological roles of the Unfolded Protein Response

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Cellular response to endoplasmic reticulum stress: a matter of life or death

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

A human scFv antibody against TRAIL receptor 2 induces autophagic cell death in both TRAIL-sensitive and TRAIL-resistant cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The role for endoplasmic reticulum stress in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Bax-dependent regulation of Bak by voltage-dependent anion channel 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Endoplasmic reticulum stress in disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The unfolded protein response and cancer: a brighter future unfolding?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The molecular mechanism of endoplasmic reticulum stress-induced apoptosis in PC-12 neuronal cells: the protective effect of insulin-like growth factor I.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Basal autophagy is involved in the degradation of the ERAD component EDEM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Exendin-4 stimulation of cyclin A2 in beta-cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Expanding role of AMPK in endocrinology.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.8.2.18807

21 January 2018

Identifiers

DOI

10.4161/AUTO.8.2.18807

1 reference

26 August 2017

1 reference