The unfolded protein response and cancer: a brighter future unfolding? (Q36704651)

15 August 2017

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title

The unfolded protein response and cancer: a brighter future unfolding? (English)

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15 August 2017

Peter Scriven

1

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15 August 2017

Nicola J Brown

series ordinal

2

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15 August 2017

A Graham Pockley

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3

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15 August 2017

Lynda Wyld

series ordinal

4

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15 August 2017

10 January 2007

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Journal of Molecular Medicine

15 August 2017

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15 August 2017

85

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15 August 2017

4

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15 August 2017

331-341

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https://scigraph.springernature.com/pub.10.1007/s00109-006-0150-5

15 August 2017

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cites work

Complex regulation of heat shock- and glucose-responsive genes in human cells

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https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

Physiological properties of malignant tumours

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

The effect of tumour-bearing on 2-deoxy[U-14C]glucose uptake in normal and neoplastic tissues in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

Depletion of topoisomerase II in isolated nuclei during a glucose-regulated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-006-0150-5

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

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12 December 2020

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

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12 December 2020

Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapy in the A549 non-small-cell lung cancer cell line

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12 December 2020

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

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12 December 2020

Association between the mammalian 110,000-dalton heat-shock protein and nucleoli

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12 December 2020

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

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12 December 2020

On the Origin of Cancer Cells

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12 December 2020

Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions

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12 December 2020

Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation

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12 December 2020

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

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12 December 2020

Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts

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12 December 2020

Immunoglobulin heavy chain binding protein

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12 December 2020

Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression

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12 December 2020

Coordinated activation of Hsp70 chaperones

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12 December 2020

Remarkable tolerance of tumor cells to nutrient deprivation: possible new biochemical target for cancer therapy

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12 December 2020

p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells.

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12 December 2020

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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12 December 2020

Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation

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12 December 2020

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

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12 December 2020

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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12 December 2020

Regulation of translational initiation during cellular responses to stress

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12 December 2020

Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression.

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12 December 2020

Stress proteins: nomenclature, division and functions.

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12 December 2020

Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

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12 December 2020

The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress

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12 December 2020

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

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12 December 2020

Evidence from transgenic mice that myc regulates hepatic glycolysis

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12 December 2020

Phase II trial of PS-341 in patients with renal cell cancer: a University of Chicago phase II consortium study

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12 December 2020

Oxygen regulated 80 kDa protein and glucose regulated 78kDa protein are identical.

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12 December 2020

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

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12 December 2020

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

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12 December 2020

Regulated translation initiation controls stress-induced gene expression in mammalian cells

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12 December 2020

Fructose 2,6-bisphosphate and the control of glycolysis by growth factors, tumor promoters and oncogenes

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12 December 2020

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

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12 December 2020

Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation- and progression-linked discriminants of malignancy.

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12 December 2020

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

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12 December 2020

The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts.

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12 December 2020

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

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12 December 2020

Proteasome inhibitor PS-341 down-regulates prostate-specific antigen (PSA) and induces growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells

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12 December 2020

Resistance to etoposide induced by three glucose-regulated stresses in Chinese hamster ovary cells.

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12 December 2020

Oxidative protein folding in eukaryotes: mechanisms and consequences

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12 December 2020

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK

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12 December 2020

Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence

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12 December 2020

The making of the mitotic chromosome: modern insights into classical questions

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12 December 2020

Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer

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12 December 2020

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

1 reference

12 December 2020

JAB1 participates in unfolded protein responses by association and dissociation with IRE1

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12 December 2020

Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor.

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12 December 2020

A stress-inducible 40 kDa protein (hsp40): purification by modified two-dimensional gel electrophoresis and co-localization with hsc70(p73) in heat-shocked HeLa cells

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12 December 2020

The relationship of N-linked glycosylation and heavy chain-binding protein association with the secretion of glycoproteins

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12 December 2020

Response of human breast cancer cells to heat shock and chemotherapeutic drugs

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12 December 2020

Identification of a mammalian 10-kDa heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitro

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12 December 2020

The expanding role of mitochondria in apoptosis

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12 December 2020

Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors

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12 December 2020

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

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12 December 2020

The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo.

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12 December 2020

Hypersensitivity to DNA cross-linking agents associated with up-regulation of glucose-regulated stress protein GRP78.

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12 December 2020

Hypoxic gene expression and metastasis

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12 December 2020

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

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12 December 2020

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

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12 December 2020

An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

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12 December 2020

The proteasome: a suitable antineoplastic target

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12 December 2020

A major collagen-binding protein of chick embryo fibroblasts is a novel heat shock protein

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12 December 2020

Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53

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12 December 2020

Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells

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12 December 2020

Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress

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12 December 2020

Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport.

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12 December 2020

The role of the unfolded protein response in tumour development: friend or foe?

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12 December 2020

Mammalian stress response: induction of the glucose-regulated protein family

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12 December 2020

Intracellular localization and partial amino acid sequence of a stress-inducible 40-kDa protein in HeLa cells

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12 December 2020

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

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12 December 2020

Expression of stress response protein glucose regulated protein-78 mediated by c-Myb

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12 December 2020

Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes

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12 December 2020

Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade

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12 December 2020

Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling

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12 December 2020

Coordinated induction of two unrelated glucose-regulated protein genes by a calcium ionophore: human BiP/GRP78 and GAPDH.

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12 December 2020

Differential induction of glucose-regulated and heat shock proteins: effects of pH and sulfhydryl-reducing agents on chicken embryo cells.

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12 December 2020

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

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12 December 2020

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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12 December 2020

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

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12 December 2020

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12 December 2020

Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.

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12 December 2020

Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.

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12 December 2020

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12 December 2020

Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation

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12 December 2020

Caspase-3 drives apoptosis in pancreatic cancer cells after treatment with gemcitabine

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12 December 2020

Heavy chain binding protein recognizes incompletely disulfide-bonded forms of vesicular stomatitis virus G protein

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12 December 2020

Glucose consumption by transplanted tumors in vivo.

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12 December 2020

DNA topoisomerases: essential enzymes and lethal targets

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12 December 2020

Oncogenic alterations of metabolism

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12 December 2020

Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans

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12 December 2020

PERK mediates cell-cycle exit during the mammalian unfolded protein response

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12 December 2020

Expression of the 100-kda glucose-regulated protein (GRP100/endoplasmin) is associated with tumorigenicity in a model of rat colon adenocarcinoma

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12 December 2020

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

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12 December 2020

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

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12 December 2020

Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

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12 December 2020

Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150

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12 December 2020

BiP is feed-back regulated by control of protein translation efficiency.

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12 December 2020

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

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12 December 2020

P58IPK, a novel endoplasmic reticulum stress-inducible protein and potential negative regulator of eIF2alpha signaling

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12 December 2020

Alterations in an IRE1-RNA complex in the mammalian unfolded protein response.

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12 December 2020

Down-regulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers.

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12 December 2020

Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins

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12 December 2020

An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: role in tumor cell glycolysis and the Warburg effect

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12 December 2020

Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells

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12 December 2020

Dependence of endoplasmic reticulum-associated degradation on the peptide binding domain and concentration of BiP.

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12 December 2020

Synergistic effect of histone deacetylase inhibitors FK228 and m-carboxycinnamic acid bis-hydroxamide with proteasome inhibitors PSI and PS-341 against gastrointestinal adenocarcinoma cells

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12 December 2020

The potential role of transformation-induced metabolic changes in tumor-host interaction.

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12 December 2020

Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs

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12 December 2020

Effect on tumor cells of blocking survival response to glucose deprivation

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12 December 2020

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

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12 December 2020

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

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12 December 2020

Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etoposide.

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12 December 2020

Antitopoisomerase drug action and resistance

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12 December 2020

Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers.

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12 December 2020

A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer

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12 December 2020

De-regulation of GRP stress protein expression in human breast cancer cell lines.

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12 December 2020

EXPERIMENTAL ACTIVATION OF SPECIFIC LOCI IN POLYTENE CHROMOSOMES OF DROSOPHILA

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12 December 2020

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

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12 December 2020

10.1007/S00109-006-0150-5

Identifiers

DOI

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15 August 2017

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