The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA. (Q37940370)

25 August 2017

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title

The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA. (English)

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25 August 2017

Gerry P Crossan

1

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author name string

Ketan J Patel

series ordinal

2

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25 August 2017

25 October 2011

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25 August 2017

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25 August 2017

226

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25 August 2017

2

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25 August 2017

326-337

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Guido Fanconi (1892-1979): a jack of all trades.

25 August 2017

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The emerging genetic and molecular basis of Fanconi anaemia

21 January 2018

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Fanconi anemia and its diagnosis

21 January 2018

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Fanconi anaemia complementation group B presenting as X linked VACTERL with hydrocephalus syndrome

21 January 2018

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Fanconi's anemia and clinical radiosensitivity report on two adult patients with locally advanced solid tumors treated by radiotherapy

21 January 2018

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A 20-year perspective on the International Fanconi Anemia Registry (IFAR).

21 January 2018

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Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis

21 January 2018

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Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage

21 January 2018

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Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients

21 January 2018

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Fanconi's anaemia and pregnancy

21 January 2018

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Mouse models of Fanconi anemia

21 January 2018

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Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

21 January 2018

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Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

21 January 2018

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A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd

21 January 2018

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Mice with a targeted disruption of the Fanconi anemia homolog Fanca

21 January 2018

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Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia

21 January 2018

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Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice

21 January 2018

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Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.

21 January 2018

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Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.

21 January 2018

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Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis

21 January 2018

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Cancer in Fanconi anemia.

21 January 2018

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Cancer incidence in persons with Fanconi anemia.

21 January 2018

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Myelodysplastic syndrome.

21 January 2018

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The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML).

21 January 2018

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Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients

21 January 2018

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Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry

21 January 2018

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Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins.

21 January 2018

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In utero origins of childhood leukaemia

21 January 2018

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Leukemia in twins: lessons in natural history

21 January 2018

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Origins of chromosome translocations in childhood leukaemia

21 January 2018

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Blood group chimerism in human multiple births is not rare

21 January 2018

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Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights

21 January 2018

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Fanconi anemia and DNA replication repair

21 January 2018

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Determination of cisplatin 1,2-intrastrand guanine-guanine DNA adducts in human leukocytes by high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry.

21 January 2018

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Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens

21 January 2018

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The genetic and molecular basis of Fanconi anemia

21 January 2018

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SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

21 January 2018

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Mutations of the SLX4 gene in Fanconi anemia

21 January 2018

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Mutation of the RAD51C gene in a Fanconi anemia-like disorder

21 January 2018

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Cloning of cDNAs for Fanconi's anaemia by functional complementation

21 January 2018

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Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3.

21 January 2018

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Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9

21 January 2018

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Variable pathogenicity of exon 43del (FAA) in four Fanconi anaemia patients within a consanguineous family

21 January 2018

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Natural gene therapy in monozygotic twins with Fanconi anemia

21 January 2018

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Xpf and not the Fanconi anaemia proteins or Rev3 accounts for the extreme resistance to cisplatin in Dictyostelium discoideum

21 January 2018

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

21 January 2018

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Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin

21 January 2018

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FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

21 January 2018

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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

21 January 2018

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Monoubiquitylation in the Fanconi anemia DNA damage response pathway

21 January 2018

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A novel ubiquitin ligase is deficient in Fanconi anemia

21 January 2018

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A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

21 January 2018

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FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway

21 January 2018

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The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.

21 January 2018

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The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly

21 January 2018

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FANCE: the link between Fanconi anaemia complex assembly and activity

21 January 2018

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Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway

21 January 2018

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FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

21 January 2018

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The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair

21 January 2018

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Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination

21 January 2018

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The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

21 January 2018

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The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

21 January 2018

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Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM

21 January 2018

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FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3

21 January 2018

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Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.

21 January 2018

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A role for PCNA ubiquitination in immunoglobulin hypermutation

21 January 2018

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Deoxycytidyl transferase activity of yeast REV1 protein

21 January 2018

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Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1

21 January 2018

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The 4N cell cycle delay in Fanconi anemia reflects growth arrest in late S phase

21 January 2018

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Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells

21 January 2018

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Mechanism of replication-coupled DNA interstrand crosslink repair

21 January 2018

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The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair

21 January 2018

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Mechanism of RAD51-dependent DNA interstrand cross-link repair.

21 January 2018

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Checkpoint signaling from a single DNA interstrand crosslink

21 January 2018

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Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents

21 January 2018

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FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair

21 January 2018

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Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2

21 January 2018

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A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair

21 January 2018

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KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

21 January 2018

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Human Mus81 and FANCB independently contribute to repair of DNA damage during replication

21 January 2018

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The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks

21 January 2018

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Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis

21 January 2018

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Involvement of mammalian Mus81 in genome integrity and tumor suppression

21 January 2018

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Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease

21 January 2018

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The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells

21 January 2018

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The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells

21 January 2018

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Yeast DNA repair and recombination proteins Rad1 and Rad10 constitute a single-stranded-DNA endonuclease

21 January 2018

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Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease

21 January 2018

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Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

21 January 2018

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Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF

21 January 2018

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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

21 January 2018

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XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

21 January 2018

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Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice

21 January 2018

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DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse

21 January 2018

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Structural and functional relationships of the XPF/MUS81 family of proteins

21 January 2018

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DNA structural elements required for ERCC1-XPF endonuclease activity.

21 January 2018

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Processing of a psoralen DNA interstrand cross-link by XPF-ERCC1 complex in vitro

21 January 2018

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Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

21 January 2018

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Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

21 January 2018

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Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

21 January 2018

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Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination

21 January 2018

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Genomic screening in vivo reveals the role played by vacuolar H+ ATPase and cytosolic acidification in sensitivity to DNA-damaging agents such as cisplatin

21 January 2018

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Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

21 January 2018

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Slx4 becomes phosphorylated after DNA damage in a Mec1/Tel1-dependent manner and is required for repair of DNA alkylation damage

21 January 2018

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Characterization of molecular defects in xeroderma pigmentosum group F in relation to its clinically mild symptoms

21 January 2018

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Sequential assembly of the nucleotide excision repair factors in vivo

21 January 2018

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Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA

21 January 2018

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The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways

21 January 2018

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Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde

21 January 2018

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Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

21 January 2018

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Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

21 January 2018

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Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health

21 January 2018

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Identification of DNA adducts of acetaldehyde.

21 January 2018

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Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells

21 January 2018

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[13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells

21 January 2018

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Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links.

21 January 2018

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Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA.

21 January 2018

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X-linked inheritance of Fanconi anemia complementation group B

21 January 2018

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Cloning of cDNAs for Fanconi's anaemia by functional complementation

21 January 2018

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Biallelic inactivation of BRCA2 in Fanconi anemia

21 January 2018

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BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

21 January 2018

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Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway

21 January 2018

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The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM

21 January 2018

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Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex

21 January 2018

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Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

21 January 2018

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Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

21 January 2018

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Complex chromosomal abnormalities in utero, 5 years before leukaemia*

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.3002

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25 August 2017

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PubMed ID

21956823