Protein engineering to stabilize soluble amyloid β-protein aggregates for structural and functional studies (Q37913546)

25 August 2017

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title

Protein engineering to stabilize soluble amyloid β-protein aggregates for structural and functional studies (English)

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25 August 2017

Torleif Härd

1

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language of work or name

English

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publication date

6 September 2011

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25 August 2017

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25 August 2017

278

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25 August 2017

3884-3892

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25 August 2017

20

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

25 August 2017

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Amyloid β-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Amyloid beta-protein assembly and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Biophysical analyses of synthetic amyloid-beta(1-42) aggregates before and after covalent cross-linking. Implications for deducing the structure of endogenous amyloid-beta oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Structure-neurotoxicity relationships of amyloid beta-protein oligomers

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

A disulfide-linked amyloid-beta peptide dimer forms a protofibril-like oligomer through a distinct pathway from amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Structural characterization of a soluble amyloid beta-peptide oligomer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Molecular engineering of a secreted, highly homogeneous, and neurotoxic aβ dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Abeta-globulomers are formed independently of the fibril pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Neurodegenerative disease: amyloid pores from pathogenic mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

High-molecular-weight beta-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Dramatic stabilization of the native state of human carbonic anhydrase II by an engineered disulfide bond

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Rational engineering of enzyme stability

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Conformational stabilization of an engineered binding protein.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Disulfide by Design™: a computational method for the rational design of disulfide bonds in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Stabilization of a -hairpin in monomeric Alzheimer's amyloid- peptide inhibits amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Interaction of Alzheimer's A beta peptide with an engineered binding protein--thermodynamics and kinetics of coupled folding-binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

On the nucleation of amyloid beta-protein monomer folding

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Structure-activity relationship of amyloid fibrils.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Structure of the cross-beta spine of amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

An analytical solution to the kinetics of breakable filament assembly

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Recombinant amyloid beta-peptide production by coexpression with an affibody ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

Substantial increase of protein stability by multiple disulphide bonds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2011.08295.X

10.1111/J.1742-4658.2011.08295.X

21 January 2018

Identifiers

DOI

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25 August 2017

1 reference

PubMed ID

21824290