Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies (Q42163313)

17 October 2017

Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies (English)

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17 October 2017

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7

Konrad Beyreuther

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17 October 2017

9

Gerd Multhaup

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17 October 2017

Ariane Schmechel

1

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17 October 2017

Hanswalter Zentgraf

2

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17 October 2017

Stefan Scheuermann

3

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17 October 2017

Guenter Fritz

4

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17 October 2017

Rüdiger Pipkorn

5

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17 October 2017

Jennifer Reed

6

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17 October 2017

Thomas A Bayer

8

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17 October 2017

language of work or name

English

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publication date

1 July 2003

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Journal of Biological Chemistry

17 October 2017

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17 October 2017

278

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17 October 2017

35317-35324

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17 October 2017

37

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The molecular significance of amyloid beta-peptide for Alzheimer's disease

17 October 2017

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Amino-terminal deletions enhance aggregation of beta-amyloid peptides in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Localization of a fibrillar amyloid beta-protein binding domain on its precursor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrations

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

A conformation change in the carboxyl terminus of Alzheimer's Abeta (1-40) accompanies the transition from dimer to fibril as revealed by fluorescence quenching analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

A set of constructed type spectra for the practical estimation of peptide secondary structure from circular dichroism.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

9-Fluorenylmethoxycarbonyl amino-protecting group

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Evidence for a copper-binding superfamily of the amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

The metabolic pathway generating p3, an A beta-peptide fragment, is probably non-amyloidogenic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Abeta 17-42 in Alzheimer's disease activates JNK and caspase-8 leading to neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Characterization of murine immunoglobulin G antibodies against human amyloid-beta1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Growth of beta-amyloid(1-40) protofibrils by monomer elongation and lateral association. Characterization of distinct products by light scattering and atomic force microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Exposing asymmetry between monomers in Alzheimer's amyloid fibrils via reductive alkylation of lysine residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Stabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

An atomic model for the pleated beta-sheet structure of abeta amyloid protofilaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Propagating structure of Alzheimer's beta-amyloid(10-35) is parallel beta-sheet with residues in exact register

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Amyloid fibrillogenesis: themes and variations

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M303547200

Infrared spectroscopy applied to biochemical and biological problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303547200

21 January 2018

Identifiers

DOI

10.1074/JBC.M303547200

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17 October 2017

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