Novel therapies targeting inner mitochondrial membrane--from discovery to clinical development (Q37884459)

24 August 2017

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title

Novel therapies targeting inner mitochondrial membrane--from discovery to clinical development (English)

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24 August 2017

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Hazel H Szeto

1

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PubMed ID

21638136

24 August 2017

Peter W Schiller

series ordinal

2

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24 August 2017

3 June 2011

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24 August 2017

Pharmaceutical Research

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24 August 2017

28

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24 August 2017

11

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24 August 2017

2669-2679

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Mitochondrial DNA mutations in human disease

24 August 2017

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial oxidative stress and mammalian healthspan

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Oxidative stress as a major culprit in kidney disease in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

The mitochondrial permeability transition pore and its role in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial targets of drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial dysfunction by synthetic ligands of peroxisome proliferator activated receptors (PPARs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Fenofibrate impairs rat mitochondrial function by inhibition of respiratory complex I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial formation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Complex III releases superoxide to both sides of the inner mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial ROS-induced ROS release: an update and review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial DNA alterations and reduced mitochondrial function in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial metabolism of reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Inactivation of human manganese-superoxide dismutase by peroxynitrite is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Overexpression of Mn superoxide dismutase does not increase life span in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Extension of murine life span by overexpression of catalase targeted to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Synthesis and in vitro opioid activity profiles of DALDA analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Profound spinal tolerance after repeated exposure to a highly selective mu-opioid peptide agonist: role of delta-opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Transcellular transport of a highly polar 3+ net charge opioid tetrapeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Comparison of [Dmt1]DALDA and DAMGO in Binding and G Protein Activation at μ, δ, and κ Opioid Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Enkephalins are transported by a novel eukaryotic peptide uptake system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Structure-permeation relations of met-enkephalin peptide analogues on absorption and secretion mechanisms in Caco-2 monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Live-cell analysis of cell penetration ability and toxicity of oligo-arginines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Structural and conformational relationships between the enkephalins and the opiates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Requirements for superoxide-dependent tyrosine hydroperoxide formation in peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondria-penetrating peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Development of mitochondria-targeted aromatic-cationic peptides for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Ectopic catalase expression in mitochondria by adeno-associated virus enhances exercise performance in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

A highly potent peptide analgesic that protects against ischemia-reperfusion-induced myocardial stunning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

A potent opiate agonist protects against myocardial stunning during myocardial ischemia and reperfusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Oxidative stress and disuse muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

A novel cell-permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-011-0476-8

The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans

21 January 2018

1 reference

12 December 2020

Superoxide radical inhibits catalase

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12 December 2020

In vivo pharmacokinetics of selective mu-opioid peptide agonists

1 reference

12 December 2020

Cell-permeable peptide antioxidants as a novel therapeutic approach in a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy

1 reference

12 December 2020

Potent mitochondria-targeted peptides reduce myocardial infarction in rats

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12 December 2020

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

1 reference

12 December 2020

Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster

1 reference

12 December 2020

Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria

1 reference

12 December 2020

Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury

1 reference

12 December 2020

Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness

1 reference

12 December 2020

Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons

1 reference

12 December 2020

Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?

1 reference

12 December 2020

10.1007/S11095-011-0476-8

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21638136