Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria (Q44451554)

3 December 2017

Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria (English)

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3 December 2017

1 reference

Carlos Fonck

1

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PubMed ID

12763610

3 December 2017

Michel Baudry

series ordinal

2

1 reference

PubMed ID

12763610

3 December 2017

language of work or name

English

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publication date

1 June 2003

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3 December 2017

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3 December 2017

975

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3 December 2017

1-2

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3 December 2017

214-221

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MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes.

3 December 2017

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Salen-manganese complexes are superoxide dismutase-mimics

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Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

7 January 2021

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 January 2021

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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

7 January 2021

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Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain

7 January 2021

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Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

7 January 2021

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Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: suppression by clorgyline and deprenyl

7 January 2021

1 reference

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Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement

7 January 2021

1 reference

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MPTP fails to induce lipid peroxidation in vivo

7 January 2021

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Chronic parkinsonism secondary to intravenous injection of meperidine analogues

7 January 2021

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Animal models of PD: pieces of the same puzzle?

7 January 2021

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ATP enhances catecholamine uptake into PC12 cells

7 January 2021

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MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress.

7 January 2021

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Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo

7 January 2021

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Toxic effects of MPP(+) and MPTP in PC12 cells independent of reactive oxygen species formation

7 January 2021

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Characterization of two novel redox groups in the respiratory NADH:ubiquinone oxidoreductase (complex I).

7 January 2021

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Vitamin E supplements fail to protect mice from acute MPTP neurotoxicity.

7 January 2021

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Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse

7 January 2021

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1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles

7 January 2021

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Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.

7 January 2021

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[3H]mazindol binding associated with neuronal dopamine uptake sites in corpus striatum membranes.

7 January 2021

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Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

7 January 2021

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

7 January 2021

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Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

7 January 2021

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Mitochondrial toxin inhibition of [(3)H]dopamine uptake into rat striatal synaptosomes

7 January 2021

1 reference

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The high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopaminergic neurons from the substantia nigra.

7 January 2021

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Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism.

7 January 2021

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Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP).

7 January 2021

1 reference

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Firefly luciferase luminescence assays using scintillation counters for quantitation in transfected mammalian cells

7 January 2021

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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

7 January 2021

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Production of reactive oxygen by mitochondria from normoxic and hypoxic rat heart tissue

7 January 2021

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Chronic supranigral infusion of BDNF in normal and MPTP-treated common marmosets.

7 January 2021

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Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse.

7 January 2021

1 reference

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Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

7 January 2021

1 reference

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Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase.

7 January 2021

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EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology

7 January 2021

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro

7 January 2021

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Transgenic murine dopaminergic neurons expressing human Cu/Zn superoxide dismutase exhibit increased density in culture, but no resistance to methylphenylpyridinium-induced degeneration

7 January 2021

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Protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity by the antioxidant ascorbic acid.

7 January 2021

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Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells.

7 January 2021

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An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.

7 January 2021

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Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

7 January 2021

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10.1016/S0006-8993(03)02675-1

7 January 2021

Identifiers

DOI

1 reference

3 December 2017

1 reference

PubMed ID

12763610