The role of Smad signaling in hematopoiesis and translational hematology (Q37874928)

24 August 2017

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title

The role of Smad signaling in hematopoiesis and translational hematology (English)

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24 August 2017

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U Blank

1

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PubMed ID

21566654

24 August 2017

S Karlsson

series ordinal

2

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24 August 2017

13 May 2011

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24 August 2017

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24 August 2017

25

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24 August 2017

9

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24 August 2017

1379-1388

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https://scigraph.springernature.com/pub.10.1038/leu.2011.95

24 August 2017

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cites work

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Role of transforming growth factor-beta superfamily signaling pathways in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

The role of Smad signaling in hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Autocrine transforming growth factor-beta regulation of hematopoiesis: many outcomes that depend on the context

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Smad transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Molecular mechanism of transforming growth factor beta-mediated cell-cycle modulation in primary human CD34(+) progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Transforming growth factor beta 1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21(Cip1/Waf1) or p27(Kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Quantitative trait analysis reveals transforming growth factor-beta2 as a positive regulator of early hematopoietic progenitor and stem cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

The positive regulatory effect of TGF-beta2 on primitive murine hemopoietic stem and progenitor cells is dependent on age, genetic background, and serum factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Long-term propagation of distinct hematopoietic differentiation programs in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

A major role of TGF-beta1 in the homing capacities of murine hematopoietic stem cell/progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

TIF1gamma controls erythroid cell fate by regulating transcription elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

BMP4 and Madh5 regulate the erythroid response to acute anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Generation of mice with a conditional allele for Trim33.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

BMP4: its role in development of the hematopoietic system and potential as a hematopoietic growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Primitive erythropoiesis is regulated by Smad-dependent signaling in postgastrulation mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Bone morphogenetic protein 4 induces efficient hematopoietic differentiation of rhesus monkey embryonic stem cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Smad1 and Smad5 differentially regulate embryonic hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Smad5 is dispensable for adult murine hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Identification of the haematopoietic stem cell niche and control of the niche size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

The AFT024 stromal cell line supports long-term ex vivo maintenance of engrafting multipotent human hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Bone morphogenetic protein 4 contributes to the maintenance of primitive cord blood hematopoietic progenitors in an ex vivo stroma-noncontact co-culture system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

A road map toward defining the role of Smad signaling in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Smad7 promotes self-renewal of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Smad7 alters cell fate decisions of human hematopoietic repopulating cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Smad4 is critical for self-renewal of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Role of transforming growth factor-beta in hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Transforming growth factor-beta signaling in normal and malignant hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Smad3 mutant mice develop metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Acute myelogenous leukemia-derived SMAD4 mutations target the protein to ubiquitin-proteasome degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

A dominant inhibitory mutant of the type II transforming growth factor beta receptor in the malignant progression of a cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

p27KIP1 deletions in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Inhibition of the transforming growth factor beta 1 signaling pathway by the AML1/ETO leukemia-associated fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Molecular mechanisms of leukemogenesis by AML1/EVI-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

TGFbeta/BMP inhibits the bone marrow transformation capability of Hoxa9 by repressing its DNA-binding ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

TGF-beta1 induces bone marrow reticulin fibrosis in hairy cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Regulation of hematopoietic stem cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Side effects of retroviral gene transfer into hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

A role for Wnt signalling in self-renewal of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF- 1 in the development of myelofibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

Transforming growth factor-beta 1 delays formation of granulocyte-macrophage colony-forming cells, but spares more primitive progenitors during ex vivo expansion of CD34+ haemopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

7 January 2021

p21(cip1) mRNA is controlled by endogenous transforming growth factor-beta1 in quiescent human hematopoietic stem/progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

7 January 2021

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

7 January 2021

Microsatellite mutations of transforming growth factor-beta receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

7 January 2021

Germline mutation of the p27/Kip1 gene in childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

7 January 2021

Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

7 January 2021

In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.95

7 January 2021

Identifiers

DOI

10.1038/LEU.2011.95

1 reference

24 August 2017

1 reference

PubMed ID

21566654