TGF-β signalling from cell membrane to nucleus through SMAD proteins (Q28131770)

27 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9393997

27 November 2024

3

P. ten Dijke

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9393997

27 November 2024

author name string

C. H. Heldin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9393997

27 November 2024

K. Miyazono

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9393997

http://www.nature.com/articles/37284.pdf

27 November 2024

publication date

4 December 1997

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language of work or name

English

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work available at URL

1 reference

http://www.nature.com/articles/37284

27 November 2024

1 reference

http://www.nature.com/doifinder/10.1038/37284

27 November 2024

1 reference

publication type of scholarly work

27 November 2024

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390

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issue

6659

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page(s)

465-71

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review article

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TGF-beta signalling through the Smad pathway

cites work

1 reference

7 January 2021

Mechanism of activation of the TGF-beta receptor

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The types II and III transforming growth factor-beta receptors form homo-oligomers

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Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction.

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Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors

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Activation of signalling by the activin receptor complex

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Cooperative Binding of Transforming Growth Factor (TGF)-β2 to the Types I and II TGF-β Receptors

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Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs

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Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors

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Cloning and characterization of a human type II receptor for bone morphogenetic proteins

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Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

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Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

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A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity

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Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1.

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Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis

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Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.

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Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues

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The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues

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Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

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7 January 2021

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily

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A human Mad protein acting as a BMP-regulated transcriptional activator

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7 January 2021

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

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7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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7 January 2021

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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7 January 2021

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

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7 January 2021

Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins

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7 January 2021

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

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7 January 2021

Smad5 induces ventral fates in Xenopus embryo

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7 January 2021

Cloning and characterization of a novel member of the human Mad gene family (MADH6)

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7 January 2021

Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1

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7 January 2021

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth

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7 January 2021

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

1 reference

7 January 2021

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

1 reference

7 January 2021

TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling

1 reference

7 January 2021

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

7 January 2021

Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4

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7 January 2021

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

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7 January 2021

Genetic and biochemical analysis of TGF beta signal transduction

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7 January 2021

Characterization of functional domains within Smad4/DPC4

1 reference

7 January 2021

The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation

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7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

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7 January 2021

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1 reference

7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

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7 January 2021

Smad6 inhibits signalling by the TGF-β superfamily

1 reference

7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

7 January 2021

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7 January 2021

Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

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7 January 2021

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

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7 January 2021

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse

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7 January 2021

Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos.

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7 January 2021

Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.

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7 January 2021

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex

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7 January 2021

Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

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7 January 2021

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

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7 January 2021

A transcriptional partner for MAD proteins in TGF-beta signalling

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7 January 2021

Smad4 and FAST-1 in the assembly of activin-responsive factor

1 reference

7 January 2021

The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family

1 reference

7 January 2021

Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.

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7 January 2021

FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors

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7 January 2021

The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors

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7 January 2021

Mechanism of TGFβ receptor inhibition by FKBP12

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7 January 2021

Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor

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7 January 2021

Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells

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7 January 2021

The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling

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7 January 2021

Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin

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7 January 2021

A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor

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7 January 2021

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

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7 January 2021

Altered transforming growth factor signaling in epithelial cells when ras activation is blocked

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7 January 2021

Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression

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7 January 2021

Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

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7 January 2021

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

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7 January 2021

Tumor suppressor activity of the TGF-beta pathway in human cancers

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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7 January 2021

Mad-related genes in the human

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7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

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7 January 2021

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

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7 January 2021

Cdc25 cell-cycle phosphatase as a target of c-myc

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7 January 2021

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

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7 January 2021

STATs: signal transducers and activators of transcription

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7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

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7 January 2021

Establishment of lipopolysaccharide-dependent nuclear factor kappa B activation in a cell-free system

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Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade

27 November 2024

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27 November 2024

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M Schutte

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Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4

27 November 2024

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Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1

27 November 2024

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27 November 2024

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RS Frey

1997

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27 November 2024

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