Smad3 Mutant Mice Develop Metastatic Colorectal Cancer (Q45345236)

13 December 2017

title

Smad3 mutant mice develop metastatic colorectal cancer (English)

1 reference

13 December 2017

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer (English)

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(00)81730-4

11 January 2025

1 reference

Y. Zhu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9753318

11 January 2025

J. A. Richardson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9753318

11 January 2025

L. F. Parada

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9753318

11 January 2025

J. M. Graff

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9753318

11 January 2025

publication date

1 September 1998

1 reference

13 December 2017

18 September 1998

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9753318

http://www.cell.com/article/S0092867400817304/pdf

11 January 2025

language of work or name

English

0 references

work available at URL

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9753318

https://api.elsevier.com/content/article/PII:S0092867400817304?httpAccept=text/xml

11 January 2025

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(00)81730-4

https://api.elsevier.com/content/article/PII:S0092867400817304?httpAccept=text/plain

11 January 2025

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(00)81730-4

11 January 2025

1 reference

13 December 2017

volume

94

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13 December 2017

issue

6

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13 December 2017

page(s)

703-714

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Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers

13 December 2017

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Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

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Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

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Intracellular signalling: the mad way to do it.

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Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

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7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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Embryonic patterning: to BMP or not to BMP, that is the question

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Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily

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Identification and characterization of the familial adenomatous polyposis coli gene

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TGF-β signalling from cell membrane to nucleus through SMAD proteins

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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

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Effects of an Rb mutation in the mouse

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Tumor spectrum analysis in p53-mutant mice

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Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

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7 January 2021

Colon cancer and DNA repair: have mismatches met their match?

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7 January 2021

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

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7 January 2021

Lessons from hereditary colorectal cancer

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The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

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7 January 2021

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

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7 January 2021

A human Mad protein acting as a BMP-regulated transcriptional activator

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7 January 2021

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

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7 January 2021

HNPCC associated with germline mutation in the TGF-β type II receptor gene

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

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7 January 2021

Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway

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7 January 2021

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

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7 January 2021

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

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7 January 2021

Mutation of a mutL homolog in hereditary colon cancer

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7 January 2021

Hypermutability and mismatch repair deficiency in RER+ tumor cells

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7 January 2021

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

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7 January 2021

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

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7 January 2021

Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

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Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

11 January 2025

11

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TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

11 January 2025

47

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DPC4 gene in various tumor types

11 January 2025

48

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Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer

11 January 2025

60

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11 January 2025

Identifiers

1 reference

13 December 2017

1 reference