Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects (Q37871413)

24 August 2017

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title

Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects (English)

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24 August 2017

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Susumu Goyama

1

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PubMed ID

21537931

24 August 2017

James C Mulloy

series ordinal

2

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24 August 2017

3 May 2011

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International Journal of Hematology

24 August 2017

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24 August 2017

94

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24 August 2017

2

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24 August 2017

126-133

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https://scigraph.springernature.com/pub.10.1007/s12185-011-0858-z

24 August 2017

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cites work

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

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The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

21 January 2018

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Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

21 January 2018

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Core-binding factors in haematopoiesis and leukaemia

21 January 2018

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Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol

21 January 2018

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Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup

21 January 2018

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ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

21 January 2018

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ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

21 January 2018

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

21 January 2018

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Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

21 January 2018

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Altered affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis

21 January 2018

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The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain

21 January 2018

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Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11.

21 January 2018

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

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Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1

21 January 2018

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Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11.

21 January 2018

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AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.

21 January 2018

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AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

21 January 2018

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Erythroid inhibition by the leukemic fusion AML1-ETO is associated with impaired acetylation of the major erythroid transcription factor GATA-1.

21 January 2018

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The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

21 January 2018

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Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein.

21 January 2018

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The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

21 January 2018

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Transcriptional upregulation of p21/WAF/Cip1 in myeloid leukemic blasts expressing AML1-ETO.

21 January 2018

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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

21 January 2018

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The AML1/ETO fusion protein activates transcription of BCL-2

21 January 2018

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Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

21 January 2018

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p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

E protein silencing by the leukemogenic AML1-ETO fusion protein

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

MN1 overexpression is an important step in the development of inv(16) AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Kit ligand and c-Kit are expressed during early human ovarian follicular development and their interaction is required for the survival of follicles in long-term culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Implications of NRAS mutations in AML: a study of 2502 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

N-Ras(G12D) induces features of stepwise transformation in preleukemic human umbilical cord blood cultures expressing the AML1-ETO fusion gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Mouse models of human AML accurately predict chemotherapy response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

CBFbeta is critical for AML1-ETO and TEL-AML1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

The role of CBFbeta in AML1-ETO's activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-011-0858-Z

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

21 January 2018

1 reference

12 December 2020

Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16)

1 reference

12 December 2020

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

1 reference

12 December 2020

Modeling interactions between leukemia-specific chromosomal changes, somatic mutations, and gene expression patterns during progression of core-binding factor leukemias

1 reference

12 December 2020

Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia

1 reference

12 December 2020

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

1 reference

12 December 2020

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

1 reference

12 December 2020

The t(8;21) translocation is not consistently associated with high Bcl-2 expression in de novo acute myeloid leukemias of adults

1 reference

12 December 2020

The role of CBFbeta in AML1-ETO's activity

1 reference

12 December 2020

The molecular basis of leukemia

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12 December 2020

CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16)

1 reference

12 December 2020

10.1007/S12185-011-0858-Z

Identifiers

DOI

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24 August 2017

1 reference

PubMed ID

21537931