Notch signalling in solid tumours: a little bit of everything but not all the time (Q37867484)

24 August 2017

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title

Notch signalling in solid tumours: a little bit of everything but not all the time (English)

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24 August 2017

Prathibha Ranganathan

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1

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24 August 2017

Kelly L Weaver

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2

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24 August 2017

Anthony J Capobianco

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3

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24 August 2017

language of work or name

English

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publication date

14 April 2011

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24 August 2017

Nature Reviews Cancer

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24 August 2017

11

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24 August 2017

5

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24 August 2017

338-351

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https://scigraph.springernature.com/pub.10.1038/nrc3035

24 August 2017

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cites work

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1 reference

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

21 January 2018

1 reference

Notch and cancer: a double-edged sword

21 January 2018

1 reference

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

21 January 2018

1 reference

Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

JAGGED1 expression is associated with prostate cancer metastasis and recurrence

21 January 2018

1 reference

Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations

21 January 2018

1 reference

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

21 January 2018

1 reference

Notch signaling in leukemia

21 January 2018

1 reference

The molecular logic of Notch signaling--a structural and biochemical perspective.

21 January 2018

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Notch signalling: a simple pathway becomes complex

21 January 2018

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The canonical Notch signaling pathway: unfolding the activation mechanism

21 January 2018

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More complicated than it looks: assembly of Notch pathway transcription complexes

21 January 2018

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Notch signaling: the core pathway and its posttranslational regulation

21 January 2018

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The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

21 January 2018

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The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase

21 January 2018

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Notch-induced proteolysis and nuclear localization of the Delta ligand

21 January 2018

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Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development

21 January 2018

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Canonical and non-canonical Notch ligands

21 January 2018

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The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation

21 January 2018

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The intracellular domain of Notch ligand Delta1 induces cell growth arrest

21 January 2018

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The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4).

21 January 2018

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Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

21 January 2018

1 reference

21 January 2018

It's T-ALL about Notch

1 reference

Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic).

21 January 2018

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Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors

21 January 2018

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Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

21 January 2018

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

21 January 2018

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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

21 January 2018

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

21 January 2018

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Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

21 January 2018

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

21 January 2018

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Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.

21 January 2018

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The notch target gene HES1 regulates cell cycle inhibitor expression in the developing pituitary

21 January 2018

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Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

21 January 2018

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Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines

21 January 2018

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Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis

21 January 2018

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The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo

21 January 2018

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Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase

21 January 2018

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Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases

21 January 2018

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Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression

21 January 2018

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Overexpressed active Notch1 induces cell growth arrest of HeLa cervical carcinoma cells

21 January 2018

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Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways

21 January 2018

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Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression

21 January 2018

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Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator

21 January 2018

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Notch signaling is necessary for epithelial growth arrest by TGF-beta

21 January 2018

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Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.

21 January 2018

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Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300.

21 January 2018

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Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

21 January 2018

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Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

21 January 2018

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Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity

21 January 2018

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The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

21 January 2018

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Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway

21 January 2018

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Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells.

21 January 2018

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Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation.

21 January 2018

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Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.

21 January 2018

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Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression

21 January 2018

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Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision.

21 January 2018

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Linking colorectal cancer to Wnt signaling

21 January 2018

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

21 January 2018

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

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The Wnt antagonist sFRP1 in colorectal tumorigenesis

21 January 2018

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

21 January 2018

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WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive regulator of the WNT- beta-catenin-TCF signaling pathway

21 January 2018

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An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling

21 January 2018

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

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Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

21 January 2018

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Notch is required for wingless signaling in the epidermis of Drosophila.

21 January 2018

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Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development.

21 January 2018

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Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction

21 January 2018

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Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.

21 January 2018

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Notch1 functions as a tumor suppressor in mouse skin

21 January 2018

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p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation

21 January 2018

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Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

21 January 2018

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Notch and Kras in pancreatic cancer: at the crossroads of mutation, differentiation and signaling

21 January 2018

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Periodic Delta-like 4 expression in developing retinal arteries.

21 January 2018

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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

21 January 2018

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The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.

21 January 2018

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Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

21 January 2018

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Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer

21 January 2018

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Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

21 January 2018

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

21 January 2018

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The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

21 January 2018

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Fringe modulates Notch-ligand interactions.

21 January 2018

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Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells

21 January 2018

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Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.

21 January 2018

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Epithelial-mesenchymal transitions in development and pathologies

21 January 2018

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Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

21 January 2018

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Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

21 January 2018

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Notch signaling mediates hypoxia-induced tumor cell migration and invasion

21 January 2018

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Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

21 January 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

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The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

21 January 2018

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Prospective identification of tumorigenic breast cancer cells

21 January 2018

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Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

21 January 2018

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Pancreatic cancer stem cells.

21 January 2018

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Prostate cancer stem cells: a new target for therapy

21 January 2018

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

21 January 2018

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Cancer stem cells and the ontogeny of lung cancer

21 January 2018

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Cancer stem cells in head and neck squamous cell cancer

21 January 2018

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21 January 2018

Liver cancer stem cells

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

21 January 2018

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Tumour stem cells and drug resistance

21 January 2018

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Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

21 January 2018

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Interaction of hypoxia-inducible factor-1α and Notch signaling regulates medulloblastoma precursor proliferation and fate.

21 January 2018

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

21 January 2018

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Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

21 January 2018

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Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells

21 January 2018

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Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

21 January 2018

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Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling

21 January 2018

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gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity

21 January 2018

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Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells

21 January 2018

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Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles.

21 January 2018

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Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.

21 January 2018

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A functional Notch-survivin gene signature in basal breast cancer

21 January 2018

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Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis

21 January 2018

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Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells

21 January 2018

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Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence

21 January 2018

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Notch: Implications of endogenous inhibitors for therapy

21 January 2018

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Therapeutic antibody targeting of individual Notch receptors

21 January 2018

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Notch signaling: emerging molecular targets for cancer therapy

21 January 2018

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Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

21 January 2018

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Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

21 January 2018

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t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway

21 January 2018

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Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors

21 January 2018

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Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion

21 January 2018

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Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion

21 January 2018

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Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling.

21 January 2018

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Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing.

21 January 2018

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Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing.

21 January 2018

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Gene-specific targeting of the histone chaperone asf1 to mediate silencing

21 January 2018

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Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma

21 January 2018

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A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion

21 January 2018

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SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

21 January 2018

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FBXW7/hCDC4 is a general tumor suppressor in human cancer.

21 January 2018

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Somatic mutations of the CDC4 (FBXW7) gene in hereditary colorectal tumors.

21 January 2018

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Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein

21 January 2018

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Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

21 January 2018

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Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

21 January 2018

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NUMB controls p53 tumour suppressor activity

21 January 2018

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Human deltex is a conserved regulator of Notch signalling

21 January 2018

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Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

21 January 2018

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Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

21 January 2018

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Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis

21 January 2018

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Crosstalk of Notch with p53 and p63 in cancer growth control

31 March 2020

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Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53

31 March 2020

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Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression

31 March 2020

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Off the beaten pathway: the complex cross talk between Notch and NF-kappaB

31 March 2020

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Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

31 March 2020

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The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth

31 March 2020

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Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways

31 March 2020

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The bHLH gene hes1 as a repressor of the neuronal commitment of CNS stem cells.

31 March 2020

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Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt

31 March 2020

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ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor

31 March 2020

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JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells

31 March 2020

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12 December 2020

A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17.

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12 December 2020

NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts

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12 December 2020

Mammary stem cells and breast cancer--role of Notch signalling.

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12 December 2020

Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol

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12 December 2020

Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma.

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12 December 2020

Identification of a cancer stem cell in human brain tumors

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12 December 2020

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

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12 December 2020

Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway

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12 December 2020

Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis

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12 December 2020

Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways

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12 December 2020

Dynamics of notch expression during murine prostate development and tumorigenesis

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12 December 2020

Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients.

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12 December 2020

Identifiers

DOI

10.1038/NRC3035

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24 August 2017

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