Linking colorectal cancer to Wnt signaling (Q29619810)

Europe PubMed Central

title

Linking colorectal cancer to Wnt signaling (English)

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

30 April 2017

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Bienz M

1

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

30 April 2017

Clevers H

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

30 April 2017

language of work or name

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30 April 2017

publication date

13 October 2000

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

30 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

30 April 2017

volume

103

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

30 April 2017

page(s)

311-20

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

30 April 2017

issue

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11057903

beta-catenin is a target for the ubiquitin-proteasome pathway

30 April 2017

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NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion

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Functional interaction of beta-catenin with the transcription factor LEF-1

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Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

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Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer

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A new member of the frizzled family from Drosophila functions as a Wingless receptor

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APC: the plot thickens

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Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front.

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beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer

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pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila.

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Wnt signaling: a common theme in animal development

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The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells

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Drosophila Tcf and Groucho interact to repress Wingless signalling activity.

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The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors

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Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus

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Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin

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Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization

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Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification

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Somatic mutations of the APC gene in primary breast cancers

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De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin

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LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites.

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7 January 2021

Identification and characterization of the familial adenomatous polyposis coli gene

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7 January 2021

Identification and characterization of E-APC, a novel Drosophila homologue of the tumour suppressor APC.

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7 January 2021

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

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7 January 2021

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

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A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo

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7 January 2021

Identification of c-MYC as a target of the APC pathway

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7 January 2021

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

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7 January 2021

The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

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7 January 2021

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

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7 January 2021

Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection

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7 January 2021

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

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7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.

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Asef, a link between the tumor suppressor APC and G-protein signaling

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Lessons from hereditary colorectal cancer

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Identification of FAP locus genes from chromosome 5q21

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DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

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Axin prevents Wnt-3a-induced accumulation of beta-catenin

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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Distinct beta-catenins mediate adhesion and signalling functions in C. elegans

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Familial adenomatous polyposis

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APC mutations are sufficient for the growth of early colorectal adenomas

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7 January 2021

beta-TrCP is a negative regulator of Wnt/beta-catenin signaling pathway and dorsal axis formation in Xenopus embryos.

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

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7 January 2021

Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis

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7 January 2021

Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages

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7 January 2021

Signal transduction through beta-catenin and specification of cell fate during embryogenesis

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7 January 2021

Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells

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7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

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7 January 2021

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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7 January 2021

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

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7 January 2021

Mutations of the APC (adenomatous polyposis coli) gene

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7 January 2021

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

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7 January 2021

dishevelled and armadillo act in the wingless signalling pathway in Drosophila

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7 January 2021

An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling

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7 January 2021

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

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7 January 2021

The genetic basis of patterned baldness in Drosophila

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7 January 2021

LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic.

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7 January 2021

Mad-related genes in the human

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Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos

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The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

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Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.

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The APC tumour suppressor has a nuclear export function.

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7 January 2021

Association of the APC gene product with beta-catenin

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Stabilization of beta-catenin by genetic defects in melanoma cell lines

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Uncoupling cadherin-based adhesion from wingless signalling in Drosophila.

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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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7 January 2021

wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

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7 January 2021

Components of wingless signalling in Drosophila.

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7 January 2021

Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

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7 January 2021

Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

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7 January 2021

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

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7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

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7 January 2021

The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

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7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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7 January 2021

Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm

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Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

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7 January 2021

Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor

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Hot spots in beta-catenin for interactions with LEF-1, conductin and APC

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7 January 2021

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling.

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7 January 2021

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

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7 January 2021

Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia

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7 January 2021

beta-catenin can be transported into the nucleus in a Ran-unassisted manner

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7 January 2021

GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis

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7 January 2021

Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps.

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7 January 2021

A new Drosophila APC homologue associated with adhesive zones of epithelial cells.

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7 January 2021

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

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7 January 2021