Strength of TCR-peptide/MHC interactions and in vivo T cell responses (Q37866944)

24 August 2017

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title

Strength of TCR-peptide/MHC interactions and in vivo T cell responses (English)

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24 August 2017

3

James P Allison

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author name string

Emily Corse

series ordinal

1

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24 August 2017

Rachel A Gottschalk

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

1 May 2011

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24 August 2017

Journal of Immunology

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24 August 2017

186

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24 August 2017

5039-5045

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24 August 2017

9

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Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment

24 August 2017

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Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production

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Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

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CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate

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12 October 2022

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TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

1 reference

12 October 2022

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The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

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Complete but curtailed T-cell response to very low-affinity antigen

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Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion

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12 October 2022

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T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation

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12 October 2022

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Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery

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12 October 2022

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The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling

1 reference

12 October 2022

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The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

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Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

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Jurkat T cells and development of the T-cell receptor signalling paradigm

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Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory

1 reference

12 October 2022

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Decoding the dynamics of T cell-dendritic cell interactions in vivo.

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Phenotypic analysis of antigen-specific T lymphocytes

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Epitope density influences CD8+ memory T cell differentiation

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"MIATA"-minimal information about T cell assays

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12 October 2022

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Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties

1 reference

12 October 2022

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Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor

1 reference

12 October 2022

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Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines

1 reference

12 October 2022

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Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

1 reference

12 October 2022

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The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4+ T Cells

1 reference

12 October 2022

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Kinetic proofreading in T-cell receptor signal transduction

1 reference

12 October 2022

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Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors.

1 reference

12 October 2022

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Continuous T cell receptor signaling required for synapse maintenance and full effector potential

1 reference

12 October 2022

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Attenuated T cell responses to a high-potency ligand in vivo

1 reference

12 October 2022

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The CD28 signaling pathway regulates glucose metabolism

1 reference

12 October 2022

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Memory CD8+ T cell differentiation

1 reference

12 October 2022

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Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells

1 reference

12 October 2022

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The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

1 reference

12 October 2022

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T cell affinity maturation by selective expansion during infection

1 reference

12 October 2022

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Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy

1 reference

12 October 2022

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T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

1 reference

12 October 2022

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How T cells 'see' antigen

1 reference

12 October 2022

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Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes

1 reference

12 October 2022

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Mechanisms for T cell receptor triggering

1 reference

12 October 2022

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

1 reference

12 October 2022

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Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

1 reference

12 October 2022

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Different T cell receptor signals determine CD8+ memory versus effector development

1 reference

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Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future

1 reference

12 October 2022

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Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells

1 reference

12 October 2022

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T cells like a firm molecular handshake

1 reference

12 October 2022

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Ligand recognition by alpha beta T cell receptors

1 reference

12 October 2022

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A kinetic basis for T cell receptor repertoire selection during an immune response

1 reference

12 October 2022

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Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response

1 reference

12 October 2022

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Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

1 reference

12 October 2022

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Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen

1 reference

12 October 2022

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Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation

1 reference

12 October 2022

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

1 reference

12 October 2022

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Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

1 reference

12 October 2022

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Negative selection during the peripheral immune response to antigen

1 reference

12 October 2022

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Dynamics of Cell Surface Molecules During T Cell Recognition

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12 October 2022

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Homing and cellular traffic in lymph nodes

1 reference

12 October 2022

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Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells

1 reference

12 October 2022

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

1 reference

12 October 2022

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T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex

1 reference

12 October 2022

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Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.1003650

Inducing and expanding regulatory T cell populations by foreign antigen

1 reference

12 October 2022

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High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.1003650

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.1003650

Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope

1 reference

12 October 2022

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Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

1 reference

12 October 2022

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.1003650

T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.1003650

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

1 reference

12 October 2022

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TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

1 reference

12 October 2022

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The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse

1 reference

12 October 2022

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Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.1003650

Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions

1 reference

12 October 2022

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Kinetics and extent of T cell activation as measured with the calcium signal

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.1003650

An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.1003650

Identifiers

DOI

10.4049/JIMMUNOL.1003650

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release_gejnegnpine45ncxycbd7ojd2y

24 August 2017

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https://api.fatcat.wiki/v0/release/gejnegnpine45ncxycbd7ojd2y

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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