Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27. (Q37795583)

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14 February 2020

1 reference

8 February 2021

Regulation of antitumor immune responses by the IL-12 family cytokines, IL-12, IL-23, and IL-27 (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20885915%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

main subject

antigen-presenting cell

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18 October 2019

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20 November 2019

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8 February 2021

4

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14 February 2020

Takayuki Yoshimoto

6

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14 February 2020

author name string

Mingli Xu

1

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14 February 2020

Izuru Mizoguchi

2

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14 February 2020

Noriko Morishima

3

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14 February 2020

Junichiro Mizuguchi

5

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14 February 2020

language of work or name

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14 September 2010

5 references

3 April 2019

18 October 2019

20 November 2019

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14 February 2020

8 February 2021

Clinical and Developmental Immunology

5 references

3 April 2019

18 October 2019

20 November 2019

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14 February 2020

8 February 2021

2010

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14 February 2020

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4779-4788

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Creative Commons Attribution 3.0 Unported

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cites work

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Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice.

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The STATs of cancer--new molecular targets come of age

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Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

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Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL-6, and IL-8 responses.

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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

6 September 2017

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Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

6 September 2017

1 reference

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Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

6 September 2017

1 reference

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Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

6 September 2017

1 reference

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IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities

6 September 2017

1 reference

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Antiproliferative activity of IL-27 on melanoma

14 September 2017

1 reference

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Systemic administration of IL-23 induces potent antitumor immunity primarily mediated through Th1-type response in association with the endogenously expressed IL-12.

14 September 2017

1 reference

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Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma.

14 September 2017

1 reference

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Antiangiogenic and antitumor activities of IL-27.

14 September 2017

1 reference

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A role for IL-27 in early regulation of Th1 differentiation

14 September 2017

1 reference

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Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27.

14 September 2017

1 reference

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Antitumor effects produced by transduction of dendritic cells-derived heterodimeric cytokine genes in murine colon carcinoma cells.

14 September 2017

1 reference

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Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals.

14 September 2017

1 reference

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IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells

14 September 2017

1 reference

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An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells

14 September 2017

1 reference

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Antitumor and antimetastatic activity of interleukin 12 against murine tumors

14 September 2017

1 reference

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Role of interferon-gamma in interleukin 12-induced pathology in mice.

23 June 2018

1 reference

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Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946577

Interleukin-27 activates natural killer cells and suppresses NK-resistant head and neck squamous cell carcinoma through inducing antibody-dependent cellular cytotoxicity.

1 September 2018

1 reference

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Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946577

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946577

Swords into plowshares: IL-23 repurposes tumor immune surveillance

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946577

Potent antitumor activity of interleukin-27.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946577

WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production

1 September 2018

1 reference

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The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946577

Induction of systemic immunity by expression of interleukin-23 in murine colon carcinoma cells.

1 September 2018

1 reference

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Cytokines and soluble cytokine receptor induction after IL-12 administration in cancer patients

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2946577

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

1 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2010%2F832454

Interleukin-12: role of interferon-gamma in IL-12 adverse effects

21 January 2018

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12 December 2020

Reinforcing suppression using regulators: a new link between STAT3, IL-23, and Tregs in tumor immunosuppression

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12 December 2020

Metastatic renal cancer treated with interleukin-2 and lymphokine-activated killer cells. A phase II clinical trial

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12 December 2020

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

1 reference

12 December 2020

The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

1 reference

12 December 2020

1 reference

12 December 2020

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells

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12 December 2020

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation

1 reference

12 December 2020

IL-27-mediated activation of natural killer cells and inflammation produced antitumour effects for human oesophageal carcinoma cells

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12 December 2020

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

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12 December 2020

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells

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12 December 2020

Identifiers

DOI

10.1155/2010/832454

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20885915%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20885915%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference