Functional proteomics to dissect tyrosine kinase signalling pathways in cancer (Q37780948)

23 August 2017

Functional proteomics to dissect tyrosine kinase signalling pathways in cancer (English)

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23 August 2017

1

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23 August 2017

Andrew Pitt

2

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language of work or name

English

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publication date

19 August 2010

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23 August 2017

Nature Reviews Cancer

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23 August 2017

10

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23 August 2017

9

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23 August 2017

618-629

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https://scigraph.springernature.com/pub.10.1038/nrc2900

23 August 2017

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cites work

Linear combinations of docking affinities explain quantitative differences in RTK signaling

1 reference

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

21 January 2018

1 reference

Protein complex, gene, and regulatory modules in cancer heterogeneity

21 January 2018

1 reference

Phosphotyrosine interactome of the ErbB-receptor kinase family

21 January 2018

1 reference

Phosphatase and feedback regulation of Raf-1 signaling

21 January 2018

1 reference

Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway

21 January 2018

1 reference

Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion.

21 January 2018

1 reference

Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation

21 January 2018

1 reference

Regulation of Akt signaling activation by ubiquitination

21 January 2018

1 reference

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

21 January 2018

1 reference

Proteomic analysis of phosphorylation, oxidation and nitrosylation in signal transduction

21 January 2018

1 reference

Dissecting protein function and signaling using protein microarrays.

21 January 2018

1 reference

Biological and biomedical applications of two-dimensional vibrational spectroscopy: proteomics, imaging, and structural analysis.

31 March 2020

1 reference

Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells

31 March 2020

1 reference

Chronic myeloid leukaemia as a model of disease evolution in human cancer

31 March 2020

1 reference

An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells

31 March 2020

1 reference

Proteome survey reveals modularity of the yeast cell machinery

31 March 2020

1 reference

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

31 March 2020

1 reference

The EGF receptor family: spearheading a merger of signaling and therapeutics

31 March 2020

1 reference

Quantitative analysis of HGF and EGF-dependent phosphotyrosine signaling networks

31 March 2020

1 reference

Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer

31 March 2020

1 reference

Receptor tyrosine kinase signaling: a view from quantitative proteomics

31 March 2020

1 reference

Mapping of signaling pathways by functional interaction proteomics

31 March 2020

1 reference

Proteomics and phosphoproteomics for the mapping of cellular signalling networks

31 March 2020

1 reference

Mass spectrometry-based proteomics turns quantitative

31 March 2020

1 reference

Quantitative proteomics to study mitogen-activated protein kinases

31 March 2020

1 reference

Understanding signal transduction through functional proteomics

31 March 2020

1 reference

Proteomic characterization of the human centrosome by protein correlation profiling

31 March 2020

1 reference

Principles of cancer therapy: oncogene and non-oncogene addiction

31 March 2020

1 reference

Epidermal Growth Factor (EGF) Receptor Signaling and Cancer

31 March 2020

1 reference

Cell-signalling dynamics in time and space

31 March 2020

1 reference

Computational modeling of the EGF-receptor system: a paradigm for systems biology

31 March 2020

1 reference

A quantitative protein interaction network for the ErbB receptors using protein microarrays

31 March 2020

1 reference

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions

31 March 2020

1 reference

Epidermal growth factor receptor (EGFR) signaling in cancer

31 March 2020

1 reference

Cell fate decisions are specified by the dynamic ERK interactome

31 March 2020

1 reference

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

31 March 2020

1 reference

Optimising chronic myeloid leukaemia therapy in the face of resistance to tyrosine kinase inhibitors--a synthesis of clinical and laboratory data

31 March 2020

1 reference

The chronic myeloid leukemia stem cell

31 March 2020

1 reference

Charting the molecular network of the drug target Bcr-Abl

31 March 2020

1 reference

Antibody-based proteomics: fast-tracking molecular diagnostics in oncology.

31 March 2020

1 reference

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

31 March 2020

1 reference

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

31 March 2020

1 reference

Signaling dynamics of the KSR1 scaffold complex

31 March 2020

1 reference

A dimerization-dependent mechanism drives RAF catalytic activation

31 March 2020

1 reference

Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes

31 March 2020

1 reference

Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription

31 March 2020

1 reference

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

31 March 2020

1 reference

KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals

31 March 2020

1 reference

KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity

31 March 2020

1 reference

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

31 March 2020

1 reference

Global and site-specific quantitative phosphoproteomics: principles and applications

31 March 2020

1 reference

Large-scale proteomics analysis of the human kinome

31 March 2020

1 reference

Phosphoproteomics by mass spectrometry: insights, implications, applications and limitations

31 March 2020

1 reference

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

31 March 2020

1 reference

Phosphoproteomic approaches to elucidate cellular signaling networks

31 March 2020

1 reference

Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics

31 March 2020

1 reference

Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation

31 March 2020

1 reference

Platelet-derived growth factor receptors regulate mesenchymal stem cell fate: implications for neovascularization

31 March 2020

1 reference

An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells

31 March 2020

1 reference

The EGFRvIII variant in glioblastoma multiforme

31 March 2020

1 reference

Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

31 March 2020

1 reference

Signaling networks assembled by oncogenic EGFR and c-Met

31 March 2020

1 reference

A module of negative feedback regulators defines growth factor signaling

31 March 2020

1 reference

A review of epidermal growth factor receptor/HER2 inhibitors in the treatment of patients with non-small-cell lung cancer

31 March 2020

1 reference

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

31 March 2020

1 reference

Effects of HER2 overexpression on cell signaling networks governing proliferation and migration

31 March 2020

1 reference

Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data

31 March 2020

1 reference

The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry

31 March 2020

1 reference

Reproducible isolation of distinct, overlapping segments of the phosphoproteome

31 March 2020

1 reference

Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

31 March 2020

1 reference

Combined integrin phosphoproteomic analyses and small interfering RNA--based functional screening identify key regulators for cancer cell adhesion and migration

31 March 2020

1 reference

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.

31 March 2020

1 reference

Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins

31 March 2020

1 reference

Identification of protein O-GlcNAcylation sites using electron transfer dissociation mass spectrometry on native peptides

31 March 2020

1 reference

Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)

31 March 2020

1 reference

Ubiquitin-mediated control of oncogene and tumor suppressor gene products

31 March 2020

1 reference

Ring finger ubiquitin protein ligases and their implication to the pathogenesis of human diseases

31 March 2020

1 reference

The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation

31 March 2020

1 reference

The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation

31 March 2020

1 reference

Ubiquitin ligases: cell-cycle control and cancer

31 March 2020

1 reference

The ubiquitin-proteasome pathway and its role in cancer

31 March 2020

1 reference

p53 ubiquitination by Mdm2: a never ending tail?

31 March 2020

1 reference

Mdm2-mediated ubiquitylation: p53 and beyond.

31 March 2020

1 reference

Targeting the ubiquitin-proteasome system for cancer therapy

31 March 2020

1 reference

Targeting the ubiquitin system in cancer therapy

31 March 2020

1 reference

The ubiquitin pathway: an emerging drug target in cancer therapy

31 March 2020

1 reference

Drug discovery in the ubiquitin-proteasome system.

31 March 2020

1 reference

Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases.

31 March 2020

1 reference

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

31 March 2020

1 reference

Identification, analysis, and prediction of protein ubiquitination sites

31 March 2020

1 reference

Single cell profiling of potentiated phospho-protein networks in cancer cells.

31 March 2020

1 reference

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

31 March 2020

1 reference

An improved SUMmOn-based methodology for the identification of ubiquitin and ubiquitin-like protein conjugation sites identifies novel ubiquitin-like protein chain linkages.

31 March 2020

1 reference

A label-free quantitative proteomics strategy to identify E3 ubiquitin ligase substrates targeted to proteasome degradation.

31 March 2020

1 reference

Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays

31 March 2020

1 reference

The Nedd4-like family of E3 ubiquitin ligases and cancer

31 March 2020

1 reference

Dynamic proteomics of individual cancer cells in response to a drug.

31 March 2020

1 reference

Mapping normal and cancer cell signalling networks: towards single-cell proteomics

31 March 2020

1 reference

Cancer systems biology: a network modeling perspective

31 March 2020

1 reference

Dynamic modularity in protein interaction networks predicts breast cancer outcome

31 March 2020

1 reference

A review of quantitative methods for proteomic studies

31 March 2020

1 reference

Recent advances in 2D electrophoresis: an array of possibilities

31 March 2020

1 reference

Quantitative interaction proteomics using mass spectrometry

31 March 2020

1 reference

Liquid chromatography-mass spectrometry-based quantitative proteomics

31 March 2020

1 reference

Quantitative mass spectrometry in proteomics: a critical review

31 March 2020

1 reference

Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research.

31 March 2020

1 reference

Functional and quantitative proteomics using SILAC

31 March 2020

1 reference

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

31 March 2020

1 reference

Metabolic labeling of proteins for proteomics

31 March 2020

1 reference

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function

31 March 2020

1 reference

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

31 March 2020

1 reference

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

31 March 2020

1 reference

Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS

31 March 2020

1 reference

Quantitative protein profiling by mass spectrometry using label-free proteomics

31 March 2020

1 reference

Large-scale quantitative clinical proteomics by label-free liquid chromatography and mass spectrometry.

31 March 2020

1 reference

Antibody arrays--an emerging tool in cancer proteomics

31 March 2020

1 reference

Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions

31 March 2020

1 reference

Frontiers in fluorescence microscopy.

31 March 2020

1 reference

High-throughput kinase profiling as a platform for drug discovery

31 March 2020

1 reference

The protein kinase complement of the human genome

31 March 2020

1 reference

The (un)targeted cancer kinome

31 March 2020

1 reference

Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

31 March 2020

1 reference

Microbead arrays for the analysis of ErbB receptor tyrosine kinase activation and dimerization in breast cancer cells

31 March 2020

1 reference

Peptide reporters of kinase activity in whole cell lysates

31 March 2020

1 reference

Kinome profiling using peptide arrays in eukaryotic cells

31 March 2020

1 reference

Target profiling of small molecules by chemical proteomics

31 March 2020

1 reference

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

31 March 2020

1 reference

High throughput characterization of combinatorial histone codes

31 March 2020

1 reference

Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors

31 March 2020

1 reference

Inhibiting signal transduction: recent advances in the development of receptor tyrosine kinase and Ras inhibitors

31 March 2020

1 reference

Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes

31 March 2020

1 reference

Functional selectivity of EGF family peptide growth factors: implications for cancer

31 March 2020

1 reference

EGF-ERBB signalling: towards the systems level

31 March 2020

1 reference

The ERK signaling cascade--views from different subcellular compartments

31 March 2020

1 reference

Integrating signals from RTKs to ERK/MAPK.

31 March 2020

1 reference

MAP kinase signalling pathways in cancer

31 March 2020

1 reference

The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway

31 March 2020

1 reference

The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin

31 March 2020

1 reference

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

31 March 2020

1 reference

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology

31 March 2020

1 reference

Quantitative proteomics by stable isotope labeling and mass spectrometry

31 March 2020

1 reference

12 December 2020

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6

1 reference

12 December 2020

Proteomics modifies our understanding of cell cycle complexity

1 reference

12 December 2020

Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases

1 reference

12 December 2020

Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells

1 reference

12 December 2020

Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice

1 reference

12 December 2020

Signal transduction pathways involved in BCR-ABL transformation

1 reference

12 December 2020

Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis

1 reference

12 December 2020

Regulation of pyruvate kinase type M2 by A-Raf: a possible glycolytic stop or go mechanism

1 reference

12 December 2020

Single-cell phospho-protein analysis by flow cytometry

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NRC2900

1 reference

PubMed ID

20720570

Dimensions Publication ID

23 August 2017

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1 reference

PubMed ID

20720570